Provided is a dry yeast composition which comprises S-adenosyl-L-methionine and a thickening agent and has excellent storage stability. A thickening agent is added to a yeast cell concentrate obtained by incubating a yeast which has an SAMe-producing ability and collecting the cells, and the resultant mixture is dried. Thus, a dry yeast containing, in a high concentration, S-adenosyl-L-methionine which has excellent storage stability and excellent bioabsorbability can be easily and profitably produced. It is hence possible to supply to the market a dry yeast composition that contains, in a high concentration, S-adenosyl-L-methionine, which is useful as a water-soluble physiologically active substance, and that has excellent storage stability and bioabsorbability.本發明係提供含S-腺苷-L-甲硫胺酸與增黏劑之保存安定性佳之乾燥酵母組成物。因為藉由將具有SAMe生產能之酵母,進行培養集菌之酵母菌體濃縮物中,添加增黏劑後,進行乾燥,可簡便地且經濟地製造保存安定性,進而生物體吸收性佳之含高濃度S-腺苷-L-甲硫胺酸之乾燥酵母,所以可提供含高濃度有效地作為水溶性生理活性物質之S-腺苷-L-甲硫胺酸,保存安定性,進而生物體吸收性佳之乾燥酵母組成物於市場。