PINKERTON Anthony B. (US),ПИНКЕРТОН Энтони Б. (US),DAHL Russell (US),ДАЛЬ Расселл (US),COSFORD Nicholas D.P. (US),КОСФОРД Николас Д.П. (US),MILLAN Jose Luis (US),МИЛЛАН Хосе Луис (US),PINKERTON Anthony B.,ПИНКЕРТОН Энтони Б.,DAHL Russell,ДАЛЬ Расселл,COSFORD Nicholas D.P.,КОСФОРД Николас Д.П.,MILLAN Jose Luis,МИЛЛАН Хосе Луис
申请号：
RU2014137402
公开号：
RU0002627701C2
申请日:
2013.02.21
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to compounds of Formula I: wherein: Y1 is a bond and Y2 is -N(R6)-； L1 and L2 are each a bond； X1 is =N- or =C(R2)-； X2 is =N- or =C(R3)-； R1 and R4 are independently selected from the group consisting of -F, -Cl, -Br, -CN, -C(O)N(R7)-R8, -C(O)-O-R9, methyl, -OMe, -OCF3, optionally substituted phenyl and optionally substituted 5- or 6-membered heteroaryl； R2, R3 and R5 are hydrogen； R6 is hydrogen； R7 is hydrogen and R8 is selected from hydrogen, optionally substituted C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl or optionally substituted phenyl； either R7 and R8 together with the nitrogen atom to which they are attached form an optionally substituted heterocycloamino which is an optionally substituted pyrrolidine, an optionally substituted piperidine, an optionally substituted morpholine or an optionally substituted piperazine； R9 is selected from hydrogen, optionally substituted C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl or optionally substituted phenyl； A is selected from the group consisting of -C(O)-N(R7)-R8 or -C(O)-O-R9, or A is , R12 and R13 are independently selected from the group consisting of hydrogen, halogen, -CN, -OH, -C(O)-O-R19, optionally substituted C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl optionally substituted with C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, optionally substituted phenyl and optionally substituted 5- or 6-membered heteroaryl, R19 is selected from the group consisting of hydrogen, optionally substituted C1-C4 lkila, C1-C4 haloalkyl, optionally substituted C3-C6 cycloalkyl and optionally substituted phenyl； and R15 represents hydrogen or C1-C4 alkyl； Wherein the substituted group is substituted by -CO2H, nitrile, hydroxyl, C1-C4 alkyl, C1-C4 alkoxy, phenyl, C3-C6 cycloalkyl or diC1-C4 alkylamine, which modulate TNAP activity.EFFECT: improved properties of compounds.14 cl, 1 tbl, 12 exИзобретение относится к соединениям Формулы I:в которой: Y1 предста
