WASLEY, Jan,ROSENTHAL, Gary J.,SUN, Xicheng,STRONG, Sarah,QIU, Jian
申请号：
ES09807378
公开号：
ES2610158T3
申请日:
2009.08.14
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I or a pharmaceutically acceptable salt thereof: ** Formula ** in which Ar is selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl, wherein the aryl is an aromatic ring system monocyclic, bicyclic or tricyclic with 5 to 14 members； and the heteroaryl is a 5-14 membered aromatic heterocycle ring having at least one heteroatom selected from nitrogen, oxygen and sulfur, which contains at least 1 carbon atom, including monocyclic, bicyclic and tricyclic ring systems, wherein the substituents for aryl and heteroaryl, they are selected from the group consisting of: -halo, -ORe ', -OC (O) Re', -NRe'Re ", -SRe ', -Re', -CN, -NO2, -CO2Re ', -C (O) NRe'Re "-C (O) Re', -OC (O) NRe'Re", -NRe "C (O) Re ', -NRe" CO2Re', -NRe "'C (O) NRe'Re ", -NRe '" SO2NRe'Re ", - NHC (NH2)>； = NH, -NRe'C (NH2)>； = NH, -NH-C (NH2)>； = NRe', - S (O) Re ', -SO2Re', -SO2NRe'Re ", -NRe" SO2Re ', -N3, -CH (Ph) z, perfluoroalkoxy and perfluoroalkyl (C1-C4), in a number that varies from zero to total number of open valences in the aromatic ring system, and where Re ', Re "and Re"' are independently selected from hydrogen, unsubstituted (C1-C8) alkyl, unsubstituted (C1-C8) heteroalkyl, unsubstituted aryl , unsubstituted heteroaryl, aryl (C1-C4) alkyl ) unsubstituted, unsubstituted (C1-C4) aryloxyalkyl, monosubstituted aryl and monosubstituted heteroaryl； R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, wherein aryl, heteroaryl and the substituents for aryl and heteroaryl are as defined above； R2 is selected from the group consisting of halogen, C1-C6 alkyl, C3-C6 cycloalkyl, cyano, nitro, CF3, carbamoyl, C1-C6 alkylcarbamoyl, amino, C1-C6 alkylamino, C1-C6 dialkylamino, C1-C6 alkoxy and C3-C6 cycloalkoxy； R3 is selected from the group consisting of hydroxyl, carbamoyl, C1-C6 alkylcarbamoyl, sulfamoyl, C1-C6 alkylsulfamoyl, C3-C6 cyc
