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Fatty acid synthase inhibitors
专利权人:
Glaxosmithkline Intellectual Property (No. 2) Limited
发明人:
GHERGUROVICH, Jonathan,MOORE, Michael,PARRISH, Cynthia,RIDGERS, Lance,YU, Hongyi
申请号:
ES12826459
公开号:
ES2608053T3
申请日:
2012.08.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound according to formula (I), ** Formula ** wherein R1 is phenyl, 5- or 6-membered heteroaryl, naphthyl, 9 or 10-membered heterocyclyl; wherein said phenyl, 5- or 6-membered heteroaryl, naphthyl, 9 or 10-membered heterocyclyl, is optionally substituted with 1 to 3 substituents independently selected from the group consisting of: C1-C6 alkyl; -CF3, C3-C7 cycloalkyl, -C (>; = O) (C1-C4) alkyl, -C1-C6 alkyl-C3-C7 cycloalkyl, -C (>; = O) -C3-C7 cycloalkyl ), -C (>; = O) (phenyl), - C (>; = O) O (C1-C4) alkyl, -C (>; = O) OH, -C (>; = O) NR5R6, -O (C2 alkyl -C4) NR5R6, phenyl, -SO2-C1-C4-alkyl, -SO2NR5R6, cyano, oxo, hydroxyl, halogen, C1-C4-alkoxy, (C3-C7) -cycloalkyl (C1-C4) -alkoxy-C1- C4-, (C1-C4) alkoxy - (C1-C4) alkyl -, -OCF3, -NR5R6, R5R6 (C1-C4) alkyl -, -NR7C (>; = O) -C1-C4 alkyl, -NR7C ( >; = O) NR5R6, -NR7SO2- (C1-C4) alkyl, -NR7SO2NR5R6 and R9; R5 is selected from the group consisting of hydrogen, C1-C4-alkyl, C3-C7-cycloalkyl, -C1-C3-alkyl-C3-C7-cycloalkyl, phenyl and -C1-C3-alkyl-phenyl; R6 is hydrogen, C1-C4 alkyl, C3-C7 cycloalkyl, or -C1-C3 alkyl-C3-C7 cycloalkyl; or R5 and R6 considered together with the nitrogen to which they are attached represent a 3-7 membered saturated ring optionally containing another heteroatom which is oxygen, nitrogen or sulfur, which is optionally substituted 1 or 2 times independently with oxo or C1- alkyl C4; R7 is hydrogen or methyl; R9 is a 5- or 6-membered heteroaryl ring containing 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur, which is optionally substituted with 1 or 2 substituents selected from halogen, C1-C4 alkyl, CF3, C1-C4 alkoxy , and -NR5R6; each R2 is selected from the group consisting of halogen, C1-C6 alkyl, hydroxyl, and C1-C4 alkoxy; R3 is selected from the group consisting of: C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 hydroxyalkyl, and C4-C6 heterocycloalkyl, wherein said C1-C6 alkyl, C3-C7 cycloalkyl, and C1-C6 hydroxyalkyl, and C4-C6 heterocycloalkyl is optionally subs
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