FLOHR, Alexander,GROEBKE ZBINDEN, Katrin,LERNER, Christian
申请号：
ES13786468
公开号：
ES2603931T3
申请日:
2013.11.04
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula (I) ** Formula ** B, is C1-C4 alkylene, C2-C4 alkenylene, -C2-C4 alkenylene, C1-C4 alkoxy, -S-C1-C4 alkyl； R, is selected from the group consisting of ** Formula ** R1 and R2, together with the nitrogen atom, to which they are attached, form a bicyclic ring system, or heterocycloalkyl, which may be substituted by 1 to 3 substituents, independently selected from the group consisting of halogen, C1-C7 alkyl, C1-C7 hydroxyalkyl, C1-C7 alkoxy, C1-C7 haloalkyl, hydroxyl and oxo； R3 is selected from hydrogen, C1-C7 alkyl, C1-C7 alkoxyalkyl, C1-C7 haloalkyl, (CH2) 1,2-C3-C5- cycloalkyl, - (CH2) 1,2-aryl, optionally substituted by alkoxy C1-C7； R4 and R5 are independently selected from hydrogen, halogen, C1-C7 alkyl, C1-C7 haloalkyl, C1-C7 hydroxyalkyl, cyano, or R4 and R5, together form a C3-C8 cycloalkyl； R6, is selected from hydrogen, C1-C7 alkyl, C1-C7 haloalkoxy, C3-C8 cycloalkyl, C1-C7 alkoxy, hydroxyl, halogen, S (O) 2-C1-C7 alkyl, -C (O) NR ' R ", NR'R", where R 'and R ", are independently selected from hydrogen, C1-C7 alkyl, or R' and R", together with the nitrogen atom, to which they are attached, they form a heterocycloalkyl, or R6 and R7, together, form a C3-C8 cycloalkyl； X, is N or C-R7, where R7 is selected from hydrogen, C1-C7 alkyl, C1-C7 alkoxy, C1-C7 haloalkyl, C3-C8 cycloalkyl, -C (O) NR'R ", wherein, R 'and R ", are selected, independently, from hydrogen and C1-C7 alkyl； And, it is N, or C-R4.Un compuesto de la fórmula (I)**Fórmula** B, es alquileno C1-C4, alquenileno C2-C4, -alquinileno C2-C4, alcoxi C1-C4, -S-alquilo C1-C4； R, se selecciona de entre el grupo consistente en**Fórmula** R1 y R2, conjuntamente con el átomo de nitrógeno, al cual se encuentran éstas unidas, forman un sistema de anillos bicíclico, ó heterocicloalquilo, el cual puede encontrarse sustituido por 1 a 3 sustituyentes, independientemente seleccionados de entre el grupo consistente en halógeno, alquilo C1-C7, hidroxialquilo C1-C7, alcoxi C1-C7, haloalquilo
