Kim F. McClure;Vincent Mascitti;Ralph P. Robinson;Michael J. Munchhof
发明人:
Vincent Mascitti,Kim F. McClure,Michael J. Munchhof,Ralph P. Robinson
申请号：
US13510129
公开号：
US20120295845A1
申请日:
2010.11.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of formula (I) wherein: X is (A) or (B)； Y is O or a bond； R1 is —C(O)—O—R3 or R2 is hydrogen, cyano, C1-C6 alkyl, or C3-C6 cycloalkyl； R5 is hydrogen, cyano, nitro, C1-C6 fluoroalkyl, C1-C6 alkyl, C1-C6 alkoxy, fluoroalkoxy, or C3-C6 cycloalkyl； R6 is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, —C(O)—NH2, or C1-C6 alkyl substituted with hydroxy or C1-C6 alkoxy； m is 1 or 2, wherein when m is 1 then R8 is hydrogen, C1-C6 alkyl, —CH2—(C1-C5)haloalkyl, C3-C6 cycloalkyl, or C1-C6 alkyl substituted with hydroxy； and when m is 2 then each R8 is independently C1-C3 alkyl or —CH2—(C1—C2)haloalkyl； modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.
