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Bipirazole derivatives as JAK inhibitors
专利权人:
Incyte Holdings Corporation
发明人:
LI, Yun-Long,ZHUO, Jincong,QIAN, Ding-Quan,MEI, Song,CAO, Ganfeng,PAN, Yongchun,LI, Qun,JIA, Zhongjiang
申请号:
ES14732705
公开号:
ES2626793T3
申请日:
2014.05.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof; where: Cy1 is phenyl, pyridyl, pyrimidinyl, pyrazinyl, or pyridazinyl, each of which is optionally substituted by 1, 2, 3, or 4 groups independently selected from R3, R4, R5, and R6; Y is N or CH; R 1 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-3 alkyl, 4-7 membered heterocycloalkyl, 4-7 membered heterocycloalkyl-C 1-3 alkyl, phenyl, phenyl- C1-3 alkyl, 5-6 membered heteroaryl or 5-6 membered heteroaryl-C1-3 alkyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from fluoro, chloro, C1- alkyl 3, -OH, -O (C1-3 alkyl), -CN, -CF3, - CHF2, -CH2F, -NH2, -NH (C1-3 alkyl), - N (C1-3 alkyl) 2, -C (>; = O) N (C1-3 alkyl) 2, -C (>; = O) NH (C1-3 alkyl), - C (>; = O) NH2, - C (>; = O) O (C1- alkyl 3), - S (>; = O) 2 (C1-3 alkyl), - S (>; = O) 2 (C3-6 cycloalkyl), - C (>; = O) (C3-6 cycloalkyl), and C (>; = O) (C1-3 alkyl); R2 is H or C1-3 alkyl; wherein said C1-3 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from, chloro, -OH, -O (C1-3 alkyl fluoro), - CN, -CF3, -CHF2, -CH2F, NH2, - NH (C1-3 alkyl), and N (C1-3 alkyl) 2; or R1 and R2, together with the nitrogen atom to which they are attached, form a 4, 5 or 6 membered heterocycloalkyl ring, which is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, -OH, -O (C1-3 alkyl), - CN, C1-3 alkyl, C1-3 haloalkyl, -NH2, -NH (C1-3 alkyl), -N (C1-3 alkyl) 2, -CH2CN, and - CH2OH ; R3 is H, F, Cl, -CN, C1-3 alkyl, C1-3 fluoroalkyl, -O (C1-3 alkyl), or -O (C1-3 fluoroalkyl); R4 is H, F, Cl, -CN, C1-3 alkyl, C1-3 fluoroalkyl, -O (C1-3 alkyl), or -OC (C1-3 fluoroalkyl); R5 is H, F, Cl, -CN, C1-3 alkyl, C1-3 fluoroalkyl, -O (C1-3 alkyl), or -OC (C1-3 fluoroalkyl); R6 is H, F, Cl, -CN, C1-3 alkyl, C1-3 fluoroalkyl, -O (C1-3 alkyl), or -OC (C1-3 fluoroalkyl); R7 is H, F, Cl, C1-3 alkyl, C1-3 haloalkyl,
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