Pyridyl compounds substituted with bicyclic heterocycle useful as kinase modulators

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专利权人:

Bristol-Myers Squibb Company

发明人:

BHIDE, Rajeev,DUNCIA, John,HYNES, John,NAIR, Satheesh,PITTS, William,KUMAR, Sreekantha,GARDNER, Daniel,MURUGESAN, Natesan,PAIDI, Venkatram,SANTELLA III, Joseph,SISTLA, Ramesh,WU, Hong

申请号：

ES13792231

公开号：

ES2616812T3

申请日:

2013.11.07

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound of Formula (II) ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt thereof, in which: (a) C2-3 hydroxyalkyl substituted with zero at 4 R1a wherein R1a is independently selected from F, Cl , - OH, -CHF2, -CN, -CF3, -OCH3 and cyclopropyl； (b) C4-8 alkyl substituted with zero at 7 R1a wherein R1a is independently selected from F, Cl, -OH, -CHF2, -CF3, -CN, -OCH3 and cyclopropyl； (c) - (CH2) 2-4NHC (O) (C1-6 alkyl), - (CH2) 2CH (CH3) NHC (O) (C1-6 alkyl), - (CH2) 2CH (CH3) NHC (O ) O (C1-6 alkyl), - (CH2) 2CH (CH3) NHC (O) (CH2) 0-1NH (C1-6 alkyl), - (CH2) 2CH (CH3) NHC (O) (CH2) 0 -1N (C1-4 alkyl) 2, - (CH2) 2CH (CH3) NHC (O) (CH2) 0-1 (C3-6 cycloalkyl), - (CH2) 2CH (CH3) NHC (O) (CH2) 0-1 (C3-6 fluorocycloalkyl), - (CH2) 2CH (CH3) NHC (O) (C1-6 hydroxyalkyl), - (CH2) 2CH (CH3) NHC (O) N (C1-3 alkyl) (phenyl ) or - (CH2) 2CH (CH3) NHC (O) (CH2) 0-1R wherein R is phenyl, morpholinyl, pyrrolidinyl, triazolyl or tetrahydropyranyl； (d) cyclohexyl substituted with zero to 2 substituents selected from -OH, -OCH3,>； = O, -NH2, C1-6 alkyl, hydroxy C1-6 alkyl, -NHS (O) 2CH3, -NO2, -C (O) NH2, -C (O) NH (C1-3 alkyl), -C (O) NH (C1-6 hydroxyalkyl), - C (O) NH (C3-6 cycloalkyl), -C (O) NH (C3 cyanocycloalkyl) -6), -NHC (O) (C1-3 alkyl), -NHC (O) (pyridinyl), - NHC (O) (morpholinyl), -NHC (O) (hydroxy bicyclo [2.2.1] heptanyl), -NHC (O) NH (C1-4 alkyl) and methyl pyrazolyl； or (e) - (CH2) 2 (phenyl) wherein said phenyl is substituted with -C (O) NH2, -C (O) NH (C1-3 alkyl) or -S (O) 2NH2； or ** Formula ** R2 is benzooxazolyl, pyrazolopyridinyl, pyrrolopyridinyl, benzothiazolyl, thiazolopyridinyl, pyrazolopyrimidinyl, benzooxadiazolyl, benzothiadiazolyl, quinolinyl, cinolinyl, quinazolinyl, quinoxalinyl, each-1,5-naphyrimidyl, substituted-2-pyrimidinyl independently selected from F, Cl, -CH3, -CN, -NH2, -OCH3,>； = O and -C (O) NH2； R3 is: (a) C2-6 alkyl or C2-6 fluoroalkyl； (b) C1-3alkyl substituted with 1 to 2 cyclopropyls； (c) C1-3 alkyl substitut

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