VAN DER PLAS, Steven Emiel,MARTINA, Sébastien Laurent Xavier,DROPSIT-MONTOVERT, Sébastien Jean-Jacques Cédric,ANDREWS, Martin James Inglis,KELGTERMANS, Hans
申请号：
ES14749783
公开号：
ES2691944T3
申请日:
2014.08.05
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound according to Formula I: ** Formula ** wherein R 1 is - mono or spirocyclic C 3-7 cycloalkyl optionally substituted with one or more independently selected R 2 groups, - 4-7 membered mono or spirocyclic heterocycloalkyl comprising one or plus heteroatoms independently selected from O, N and S, substituted with one or more independently selected R2 groups, - mono or bicyclic C6-10 aryl optionally substituted with one or more independently selected R3 groups, - 5-10 consensual mono or bicyclic heteroaryl members comprising one or more heteroatoms independently selected from N, O and S, and optionally substituted with one or more independently selected R3 groups, or - C1-6 alkyl optionally substituted with one or more independently selected R4 groups, each R2 is selected from - halo, - OH, - -CN, - - OC (>； = O) C 1-4 alkyl - - C (4 -) alkoxy - oxo, - C 1-4 alkyl (optionally substituted with one or more independently selected R5a), and - C1-4 alkoxy (optionally substituted with one or more independently selected R5a), each R3 is selected from - halo, - -OH, - -CN, - C1-4 alkyl (optionally substituted with one or more independently selected R5b), - C1-4 alkoxy (optionally substituted with one or more independently selected R5b), - C2-4 alkenyl (optionally substituted with one or more independently selected R5b), - C3-7 cycloalkyl, - 4-7 membered monocyclic heterocycloalkyl comprising one or more heteroatoms independently selected from N, O and S, and 4-7 membered monocyclic heterocycloalkenyl comprising one or more heteroatoms independently selected from N, O and S, and - monocyclic heteroaryl or 5-10-member consensus bicyclic comprising one or more heteroatoms independently selected from N, O and S, and - -NHSO2-C1-4 alkyl； each R4 is selected from - halo, - OH, - monocyclic C3-7 cycloalkyl, - -CN, and - C1-4 alkoxy (optionally substituted with one or more independently selected R5c), each R5a, R5b and R5c is independently selected from or halo, or OH, or -
