AMERIKS, Michael K.,RAVULA, Suchitra,SAVALL, Bradley M.,SWANSON, Devin M.,ZIFF, Jeannie M.,SHIREMAN, Brock T.
申请号：
ES16721040
公开号：
ES2767707T3
申请日:
2016.04.28
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound of Formula (I), and pharmaceutically acceptable salts, N-oxides or solvates thereof, ** Formula ** wherein R1 is H or halo； R6 is a member selected from the group consisting of: H, halo, -C1-5 alkyl, -C1-5 haloalkyl, -C1-5 alkoxy, -C1-5 haloalkoxy, and -CN； Z1 and Z2 are independently C or N； wherein only one of Z1 or Z2 can be N； (A) when Z1 and Z2 are C； then R2 is a member selected from the group consisting of: halo, -C1-5 haloalkoxy, -C1-5 haloalkyl, -CN, and -CH2CN； R3 is a member selected from the group consisting of: H, halo, -C1-5 alkyl, -CN and -CH2CN； R4 is a member selected from the group consisting of: H, halo, -C1-5 alkyl, -C1-5 haloalkyl, -CN and -CO2C1-5 alkyl； and R5 is a member selected from the group consisting of: halo； -CH = CH2； -C1-5 haloalkyl； -C1-5 haloalkoxy； -CH2CN； -CH (CH3) CN； -C (CH3) 2CN； -O-CH2CN； -CO2C1-5alkyl； -O-benzyl； -O35 cyclopropyl, -O-CH2-cyclopropyl； -O-acetidine substituted with -CO2tBu； -O-thiazole, cyclopropyl substituted with -CN； -cyclobutyl substituted with -CN； phenyl； phenyl substituted with -F, -CN, or -OCH3； cyclopropyl, pyridyl； pyridyl substituted with -F, -OCH3O -CF3； 1- (2-methoxyethyl) pyrazol-4-yl； 3,5-dimethylisoxazol-4-yl； 2-isopropylpyrazol-3-yl； 1H-pyrazol-4-yl； 1,5-dimethylpyrazol-4-yl)； pyrimidine-5-yl； -NHCH2furyl； -O-CH2cyclopropyl substituted with two -F； and 1-methylpyrazol-4-yl； (B) when Z1 and Z2 are C and R2 is C1-5 alkyl； then R3 is selected from the group consisting of: H, -C1-5 haloalkyl, -CN, and -CO2C1-5 alkyl； R4 is selected from the group consisting of: H, halo, -CN, and -CO2C1-5 alkyl； and R5 is selected from the group consisting of: H, halo, -C1-5 alkyl, -C1-5 haloalkyl, -C1-5 alkoxy, -C1- 5 haloalkoxy, -CN, -CO2C1-5 alkyl, phenyl, 4 -fluorophenyl and 2-fluorophenyl； (C) when Z1 and Z2 are C and R2 is -C1-5 alkoxy； then R3 is selected from the group consisting of: H, halo, and -CO2C1-5 alkyl； R4 is selected from the group consisting of: H, halo, -C1-5 alkyl and -C1-5 haloalkyl
