GELIN, Christine F.,LEBOLD, Terry P.,SHIREMAN, Brock T.,ZIFF, Jeannie M.
申请号：
ES14717576
公开号：
ES2659397T3
申请日:
2014.03.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I ** Formula ** or an enantiomer, diastereomer, tautomer or isotopic variant thereof； or a pharmaceutically acceptable salt or solvate thereof； where X is N or CR1； Y is N or CR2； R1 is H, alkoxy, halo, triazolyl, thiazolyl, pyridazinyl, pyrimidinyl, oxazolyl, isoxazolyl, oxadiazolyl, pyridyl, phenyl or pyrazolyl, wherein triazolyl, thiazolyl, pyridazinyl, pyrimidinyl, oxazolyl, isoxazolyl, pyridyl, pyridyl, pyridyl optionally substituted with up to two substituents selected from the group consisting of halo and alkyl； R2 is H, alkyl, alkoxy, or halo； Z is NH, N-CH3, N-CH2CH3, N-CH2-cyclopropyl, NC (>； = O) CH3, N-CH2CH2OCH3 or O； R3 is H, alkyl, alkoxy, halo, triazolyl, thiazolyl, pyridazinyl, pyrimidinyl, oxazolyl, isoxazolyl, oxadiazolyl, pyridyl, phenyl or pyrazolyl, wherein triazolyl, thiazolyl, pyridazinyl, pyrimidinyl, oxazolyl, isoxazolyl, oxadiazolyl, oxadiazolyl, oxadiazolyl, oxadiazolyl, oxadiazole pyrazolyl is optionally substituted with up to two substituents selected from the group consisting of halo and alkyl； R4 is H or alkyl； or R3 and R4, together with the atoms to which they are attached, form a 6-membered aryl ring or a 5- or 6-membered heteroaryl ring； R5 is phenyl, pyridyl, pyrazinyl, benzoxazolyl, pyridazinyl, naphthyridinyl or pyrimidinyl, wherein pyridyl, pyrazinyl, benzoxazolyl, pyridazinyl, naphthyridinyl or pyrimidinyl is optionally substituted with up to two groups selected from the group consisting of halo, alkoxy group, haloxy, alkoxy and alkyl； and n is 1 or 2, wherein "alkyl" is a linear or branched chain alkyl group having 1 to 12 carbon atoms in the chain or a non-aromatic mono-cyclic hydrocarbon group having 3 to 7 atoms of carbon and is optionally substituted with one or more halogen atoms.Un compuesto de fórmula I**Fórmula** o un enantiómero, diastereómero, tautómero o variante isotópica de los mismos； o una sal o solvato farmacéuticamente aceptable del mismo； donde X es N o CR1； Y es N o CR2； R1 es H, al
