ФАНГ Вэнкуй К. (US),ВАНГ Лиминг (US),КОРПУЗ Эвелин Г. (US),ЧОУ Кен (US),ИМ Вха Бин (US)
申请号：
RU2013130027/04
公开号：
RU2013130027A
申请日:
2011.11.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or their pharmaceutically acceptable salts, where: A is Saryl, heterocycle, Cycloalkyl or Cycloalkenyl, B is Saryl, heterocycle, C Cycloalkenyl； R is H, halogen, -OSalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, - OC alkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halo ene, —OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, —OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, —OCalkyl, C1-6alkyl, CN , C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； L is O, C (O), S, NH or CH； R is O, S or CH； R is H or C1-6 alkyl； L is CHR, O, S, NR or —C (O) -； D is a group of the formula or indicates the point of attachment to the rest of the molecule； R is H, ORON, carboxylic acid, ROH, Salki scrap, -S (O) H, -P (O) MeOH, -P (O) (H) OH or OR； R is H or C1-6 alkyl； a is 0, 1 or 2； b is 0 or 1； c is 0 , 1, 2 or 3； R is H, C1-6alkyl； R is H or C1-6alkyl； and R is H or C1-6alkyl； R is H, OH or C1-6alkyl； and R is H or C1-6alkyl. 2. The compound according to claim 1, characterized in that L is O.3. The compound according to claim 1, characterized in that L is S.4. The compound according to claim 1, characterized in that L is CH.5. The compound according to claim 1, characterized in that D is a group of the formula, indicates the point of attachment to the rest of the molecule. The compound according to claim 1, characterized in that1. Соединение, имеющее Формулу I, его энантиомеры, диастереоизомеры, гидраты, сольваты, кристаллические формы и индивидуальные изомеры, таутомеры или их фармацевтически приемлемые соли,где:А является Сарилом, гетероциклом, Сциклоалкилом или Сциклоалкенилом；В является Сарилом, гетероцикл
