ФАНГ Вэнкуй К. (US),ВАНГ Лиминг (US),КОРПУЗ Эвелин Г. (US),ЧОУ Кен (US),ИМ Вха Бин (US)
申请号：
RU2013130028/04
公开号：
RU2013130028A
申请日:
2011.11.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or their pharmaceutically acceptable salts, where: A is Saryl, heterocycle, Cycloalkyl or Cycloalkenyl, B is Saryl, heterocycle, C Cycloalkenyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, - OC alkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halo ene, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl , C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR hydroxyl； L is O, S or NH； R is H or C1-6alkyl； R is H or C1-6alkyl； R is H or C1-6alkyl； R is H, C1-6alkyl or Cycloalkyl； and R is H, C1-6alkyl or Cycloalkyl. 2. The compound according to claim 1, characterized in that: L is S.3. The compound according to claim 1, characterized in that: L is O.4. The compound according to claim 1, characterized in that: L is NH.5. The compound according to claim 1, characterized in that: is； appears, or. 6. A compound according to claim 1, characterized in that: is； is, or； L is O, S or NH； R is H, halogen or C1-6 alkyl； R is H, halogen or C1-6 alkyl； R is H, halogen or C1-6 alkyl； R is H, halogen , -OCalkyl or C1-6alkyl； R is H, halogen, -OCalkyl or C1-6alkyl； R is H, halogen, -OCalkyl or C1-6alkyl； R is H, halogen or C1-6alkyl； R is H, halogen1. Соединение, имеющее Формулу I, его энантиомеры, диастереоизомеры, гидраты, сольваты, кристаллические формы и индивидуальные изомеры, таутомеры или их фармацевтически приемлемые соли,где:А является Сарилом, гетероциклом, Сциклоалкилом или Сциклоалкенилом；В является Сарилом, гетероциклом, Сциклоалкилом или Сциклоалкенилом；Rявляется Н, галогеном, -OCалкилом, Салкилом, CN, C(O)R, NRRили гидр
