ФАНГ Вэнкуй К. (US),ВАНГ Лиминг (US),КОРПУЗ Эвелин Г. (US),ЧОУ Кен (US),ИМ Вха Бин (US)
申请号：
RU2013130021/04
公开号：
RU2013130021A
申请日:
2011.11.28
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or pharmaceutically acceptable salts thereof, wherein: A is Caryl, heterocycle, Cycloalkyl or Cycloalkenyl, C is Caryl, heterocycle, C Cycloalkenyl； R is H, halogen, —OCalkyl, C1-6alkyl, CN, C (O) R, NO, NRR or hydroxyl； R is H, halogen, —OCalkyl, C1-6alkyl, CN, C (O) R, NO, NRR or hydroxyl； R is H , halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NO, NRR or hydroxyl； R is H, halogen nom, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl , C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR hydroxyl； R is H or C1-6alkyl； R is H or C1-6alkyl； R is H or C1-6alkyl； R is H, C1-6alkyl or Cycloalkyl； and R is H, C 1-6 alkyl or C 1-6 cycloalkyl. 2. A compound according to claim 1, characterized in that: A is Caryl, heterocycle, Cycloalkyl or Cycloalkenyl； and B is Saril. 3. The compound according to claim 1, characterized in that: is. The compound according to claim 1, characterized in that: is ；；； or. 5. The compound according to claim 1, characterized in that: is ；；； or； appears. 6. The compound according to claim 1, characterized in that: is ；；； or； is； R is H, halogen, -OCalkyl, C1-6alkyl, CN or NO； R is H, halogen, -OCalkyl, C1-6alkyl, CN or NO； R is H, halogen, -OCalkyl, C1-6alkyl, CN or NO； R is H, halogen, - OCalkyl, C1-6alkyl, CN or NO； R is H, halogen, -OCalkyl, C1-6alkyl, CN or NO； R is H, halogen1. Соединение, имеющее Формулу I, его энантиомеры, диастереоизомеры, гидраты, сольваты, кристаллические формы и индивидуальные изомеры, таутомеры или их фармацевтически приемлемые соли,где:A является Cарилом, гетероциклом, Cциклоалкилом или Cциклоалкенилом；B является Cарилом, гетероциклом, Cциклоалкилом или Cциклоалкенилом；Rявляется H, гал
