ФАНГ Вэнкуй К. (US),ВАНГ Лиминг (US),КОРПУЗ Эвелин Г. (US),ЧОУ Кен (US),ИМ Вха Бин (US)
申请号：
RU2013130020/04
公开号：
RU2013130020A
申请日:
2011.11.14
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or pharmaceutically acceptable salts thereof, wherein A is Caryl, heterocycle, Cycloalkyl or Cycloalkenyl, B is Caryl, heterocycle, Cycloalkyl ； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl , C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OC alkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C ( O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is independently halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； L is CH ； R is O, S, C (O) or CH； R is H or C 1-6 alkyl； L is CHR, O, S, NR, direct bond or -C (O) -； R is H, OPOH, carboxylic acid, POH, C 1-6 alkyl, - S (O) H, -P (O) MeOH, -P (O) (H) OH or OR； R is H or C1-6 alkyl； a is 0, 1 or 2； b is 0 or 1； c is 0, 1, 2 and whether 3； R is H, C1-6 alkyl； R is H or C1-6 alkyl； and R is H or C1-6 alkyl； R is H, OH or C1-6 alkyl； and R is H or C1-6alkyl； provided that this compound has no structure. 2. The compound according to claim 1, characterized in that: A is Caryl or heterocycle； and B is Caryl or Cycloalkyl. 3. The compound according to claim 2, characterized in that: is； appears. 4. A compound according to claim 1, characterized in that: is； is； R is H, halogen or -C-alkyl； R is H, halogen or -C-alkyl； R is H, halogen or -C-alkyl； R is H or C-alkyl, R is1. Соединение, имеющее Формулу I, его энантиомеры, диастереоизомеры, гидраты, сольваты, кристаллические формы и индивидуальные изомеры, таутомеры или их фармацевтически приемлемые соли,где A является Cарилом, гетероциклом, Сциклоалкилом или Cциклоалкенилом；B является Cарилом, гетероциклом, Cциклоалкилом или Cциклоалкенилом；Rявляется H, галогеном,
