ФАНГ Вэнкуй К. (US),ВАНГ Лиминг (US),КОРПУЗ Эвелин Г. (US),ЧОУ Кен (US),ИМ Вха Бин (US)
申请号：
RU2013129747/04
公开号：
RU2013129747A
申请日:
2011.11.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystalline forms and individual isomers, tautomers or pharmaceutically acceptable salts thereof, wherein A is Caryl, heterocycle, Cycloalkyl or Cycloalkenyl； B is Caryl, heterocycle, Cycloalkyl ； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl , C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OC alkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is H, halogen, -Oalkyl, C1-6alkyl, CN, C ( O) R, NRR or hydroxyl； R is H, halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； R is halogen, -OCalkyl, C1-6alkyl, CN, C (O) R, NRR or hydroxyl； L is O , S, NH or CH； D is a group of the formula or, "*" indicates the point of attachment to the rest of the molecule； R is H or C1-6 alkyl； R is H or C1-6 alkyl； R is H or C1-6 alkyl； ia is 0 or 1.2. The compound according to claim 1, characterized in that L is CH.3. The compound according to claim 1, characterized in that D is a group of the formula, * indicates the point of attachment to the rest of the molecule. A compound according to claim 1, characterized in that D is a group of the formula, "*" indicates the point of attachment to the rest of the molecule. The compound according to claim 1, characterized in that it is； is； R is H, halogen or C1-6 alkyl； R is H, halogen or C1-6 alkyl； R is H, halogen or C1-6 alkyl； R is H or C1-6 alkyl； R is H or C1-6 alkyl； R is H or C1-6 alkyl H； a is 0； L is O, S, NH or CH； and D i�1. Соединение, имеющее Формулу I, его энантиомеры, диастереоизомеры, гидраты, сольваты, кристаллические формы и индивидуальные изомеры, таутомеры или их фармацевтически приемлемые соли,где A является Cарилом, гетероциклом, Cциклоалкилом или Cциклоалкенилом；B является Cарилом, гетероциклом, Cциклоалкилом или Cциклоалкенилом；Rявляется
