TRABANCO-SUAREZ, Andrés,TRESADERN, Gary,VEGA RAMIRO, Juan,CID-NUNEZ, Jose
申请号：
ES08850488
公开号：
ES2637794T3
申请日:
2008.11.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having the formula (I) ** (See formula) ** or a stereochemically isomeric form thereof, wherein R 1 is C 1-6 alkyl； C3-6 cycloalkyl； trifluoromethyl； C1-3 alkyl substituted with trifluoromethyl, 2,2,2-trifluoroethoxy, C3-7 cycloalkyl, phenyl, or phenyl substituted with C1-3 alkyl, C1-3 alkyloxy, cyano, halo, trifluoromethyl, or trifluoromethoxy； phenyl； phenyl substituted with 1 or 2 substituents selected from the group consisting of C1-3 alkyl, C1-3 alkyloxy, cyano, halo, trifluoromethyl, and trifluoromethoxy； or 4-tetrahydropyranyl； R2 is cyano, halo, trifluoromethyl, C1-3alkyl or cyclopropyl； R3 is a radical of formula (a) or (b) or (c) or (d) ** (See formula) ** R4 is hydrogen； C3-6 hydroxycycloalkyl； pyridinyl； pyridinyl substituted with one or two C1-3 alkyl groups； pyrimidinyl； pyrimidinyl substituted with one or two C1-3 alkyl groups； phenyl； phenyl substituted with 1 or 2 substituents selected from the group consisting of halo, C1-3alkyl, C1-3 hydroxyalkyl, mono- or C1-3 polyhaloalkyl, cyano, hydroxyl, amino, carboxyl, C1-3alkyloxy C1-3alkyl, C1-3 alkyloxy, mono- or polyhalo-C1-3 alkyloxy, C1-3 alkylcarbonyl, mono- and di (C1-3 alkyl) amino, and morpholinyl； or phenyl with two neighborhood substituents that taken together form a divalent radical of the formula -N>； = CH-NH- (e), -CH>； = CH-NH- (f), or -O-CH2-CH2-NH- (g)； R5 is hydrogen, fluorine, hydroxyl, C1-3 hydroxyalkyl, C1-3 hydroxyalkyloxy, C1-3 fluoroalkyl, C1-3 fluoroalkyloxy, morpholinyl or cyano； X is C or N in which case R5 represents the electronic pair in N； or R4-X-R5 represents a radical of formula (h) or (i) or (j) ** (See formula) ** ...Un compuesto que tiene la fórmula (I) **(Ver fórmula)** o una forma estereoquímicamente isomérica del mismo, en la que R1 es alquilo C1-6； cicloalquilo C3-6； trifluorometilo； alquilo C1-3 sustituido con trifluorometilo, 2,2,2-trifluoroetoxi, cicloalquilo C3-7, fenilo, o fenilo sustituido con alquilo C1-3, alquiloxi C1-3, ciano, halo, trifluoro
