BROOKS, Carl,CHEUNG, Mui,GOODMAN, Krista B.,HAMMOND, Marlys
申请号：
ES12801296
公开号：
ES2595606T3
申请日:
2012.06.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I): ** Formula ** in which R1 is hydrogen, C1-3 alkyl, CH2OH, CH2-O-CH3, CH2OCH2Ph, CH2CN, CN, halo or C (O) OCH3； R2 is independently hydrogen, CN, CF3, halo, SO2 C1-3 alkyl, C1-3 alkyl or C≡CH； R3 is hydrogen, C1-2 alkyl, CF3 or -OH； R4 is hydrogen, halo or C1-3 alkyl； X is CR4 or N； A is C1-6 alkyl unsubstituted or substituted by 1-5 substituents selected from: halo, C1-3 alkyl, C3-6 cycloalkyl, Si (CH3) 3, CN, C≡CH, OC1-3 alkyl, SME, CF3, OCF3, SCF3, C (O) ORc, C (O) (NRdRe), tetrahydrofuryl, tetrahydropyranyl, tetrahydropyrrolyl, or oxotetrahydropyrrolyl； wherein tetrahydrofuryl and tetrahydropyranyl may also be substituted with one or two C1-3 alkyl groups； or A is C5-6 cycloalkyl substituted by one or more C1-3 alkyl groups； or A is (CHRf) n- (CRaRb) - (CH2) m-Rx； Ra is hydrogen or C1-3 alkyl； wherein the C1-3 alkyl may also be substituted by one or more halos； Rb is C1-3 alkyl； or Ra and Rb together with the carbon atom to which they are attached form a C3-6 cycloalkyl group； or one of the carbon atoms in the C3-6 cycloalkyl group formed by Ra and Rb can be replaced by an oxygen atom to form an oxetane, tetrahydrofuryl or tetrahydropyranyl group； or one of the carbon atoms in the C3-6 cycloalkyl group formed by Ra and Rb can be replaced by a nitrogen atom to form a dihydropyl group which may also be substituted with SO2Me, C1-4 alkyl, or C (O alkyl) ) C1-4； Rx is hydrogen, dihydrofuryl, C (O) ORc, C (O) - (NRdRe), OC1-4 alkyl, CF3, CN, C (O) piperidinyl, C1-4 alkyl, or - OCF3； Rc is C1-4 alkyl； Rd is C1-4 alkyl or C3-6 cycloalkyl； Re is hydrogen or C1-4 alkyl, Rf is hydrogen or C1-3 alkyl； n is 1, 2 or 3； m is 0, 1, or 2. and is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula (I):**Fórmula** en el que R1 es hidrógeno, alquilo C1-3, CH2OH, CH2-O-CH3, CH2OCH2Ph, CH2CN, CN, halo o C(O)OCH3； R2 es independientemente hidrógeno, CN, CF3, halo, SO2 alquilo C1-3, alquilo C1-3 o C≡CH； R3 es hidrógeno, alquilo C1
