DONG, QING,LAWSON, JOHN DAVID,WALLACE, MICHAEL B.,KANOUNI, TOUFIKE
申请号：
ES10725338
公开号：
ES2540964T3
申请日:
2010.06.08
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: G1 is selected from the group consisting of N and CR8； R1 is selected from the group consisting of optionally substituted C3-8 cycloalkyl, optionally substituted C3-6 heterocycloalkyl, optionally substituted C5-14 aryl, optionally substituted C1-10 heteroaryl and optionally substituted C1-6 alkyl； each of R2 and R3 is independently selected from the group consisting of hydrogen and optionally substituted C1-4alkyl, or R2, R3, and the carbon atom to which they are attached form a carbonyl； R4 is selected from the group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted C1-4 alkoxy, halo, hydroxy and amino； R5 is selected from the group consisting of hydrogen, optionally substituted C1-4 alkyl, C3-8 cycloalkyl and halo； each of R6 and R7 is independently selected from the group consisting of hydrogen and optionally substituted C1-4 alkyl, or R6, R7, and the carbon atom to which they are attached form a carbonyl； R8 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, optionally substituted C1-4 alkoxy, C1-9 amide, optionally substituted C3-8 cycloalkyl, optionally substituted C5-14 aryl , optionally substituted C1-10 heteroaryl and halo, wherein C5-14 aryl refers to an unsaturated monocyclic or polycyclic conjugated hydrocarbon having aromatic character and includes phenyl, biphenyl, indenyl, cyclopentadienyl, fluorenyl and naphthyl； and with the proviso that no more than one carbonyl of R2 and R3 and R6 and R7 is formed.Un compuesto de fórmula I**Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que: G1 se selecciona entre el grupo que consiste en N y CR8； R1 se selecciona entre el grupo que consiste en cicloalquilo C3-8 opcionalmente sustituido, heterocicloalquilo C3-6 opcionalmente sustituido, arilo C5-14 opcionalmente sustituido, heteroarilo C1-10 opcionalmente sustituido y alquilo C1-6 opciona
