BALDWIN, Ian Robert,DOWN, Kenneth David,FAULDER, Paul,GAINES, Simon,HAMBLIN, Julie Nicole,JONES, Katherine Louise,LE, Joelle,LUNNISS, Christopher James,PARR, Nigel James,RITCHIE, Timothy John,SMETHURS
申请号：
ES09757568
公开号：
ES2566339T3
申请日:
2009.06.03
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I) ** Formula ** in which R1 is phenyl substituted with one or two substituents independently selected from C1-6 alkyl, -OR5, halo -CN, -COR6, CO2R7, -CONR8R9, -NR10R11, -NHCOR12, -SO2R13, - (CH2) mSO2NR14R15, -NHSO2R16 and 5-membered heteroaryl, wherein the 5-membered heteroaryl contains one or two heteroatoms independently selected from oxygen and nitrogen； or pyridinyl optionally substituted with one or two substituents independently selected from C1-6 alkyl, -OR17, halo, -SO2R18, -SO2NR19R20, -NHSO2R21 and -NHCOR24； R2 is - (CH2) n-phenyl optionally substituted with -CN or -NR22R23； 5 or 6 member heteroaryl in which the 5 or 6 member heteroaryl contains one or two heteroatoms independently selected from oxygen, nitrogen and sulfur, and is optionally substituted with C1-6 alkyl, halo or - (CH2) qNR25R26； or C3-6 cycloalkyl optionally substituted with phenyl； R3 is hydrogen or fluorine； R4 is hydrogen or methyl； R7, R17, R19, R20, R22, R23, R27, R28 and R29 are each independently hydrogen or C1-6 alkyl； R5 is hydrogen, C1-6 alkyl or -CF3； R6, R12, R13, R18, R33 and R34 are each independently C1-6 alkyl； R8 and R9 are each independently hydrogen or C1-6 alkyl, or R8 and R9, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom； R10 and R11 are each independently hydrogen or C1-6 alkyl, or R10 and R11, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom； R14 and R15 are each independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl or - (CH2) pphenyl, or R14 and R15, together with the nitrogen atom to which they are attached, bind to form a heterocyclyl of 5 or 6 members optionally containing an oxygen atom； R16 is C1-6 alkyl； or phenyl optionally substituted with C1-6 alkyl； R21 is C3-6 cycloalkyl； C1-6 alkyl optionally substituted with -CF3； phenyl optionally s
