AEBI, JOHANNES,BINGGELI, ALFRED,GREEN, LUKE,HARTMANN, GUIDO,MAERKI, HANS P.,MATTEI, PATRIZIO
申请号：
ES10765643
公开号：
ES2531986T3
申请日:
2010.10.18
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** in which it is a single bond； A is phenyl or naphthyl, wherein said phenyl is optionally substituted with one to three substituents selected from the group consisting of halogen, halo C1-6 alkyl and halo C1-6 alkoxy； L is a bond, N (R ') - C (>； = O), NH-C (>； = S) or CH>； = CH-C (>； = O), in which R' is hydrogen or C1- alkyl 4； R1 and R2, together with the nitrogen atom to which they are attached, form a heterocyclyl optionally substituted with one to three substituents independently selected from the group consisting of Rd, and in which one of the carbon atoms in the ring of said heterocyclyl formed by R1 and R2 is optionally replaced by C>； = O or SO2； and / or one of the carbon atoms in the heterocyclyl ring formed by R1 and R2 is also a ring carbon atom, another ring that is C3-7 cycloalkyl or heterocyclyl, which is optionally substituted with C1-6 alkyl and wherein one or two carbon atoms in the ring of said other ring are optionally replaced by a carbonyl group； R3 and R4 are, independently of each other, selected from the group consisting of: - hydrogen, - hydroxy, - C1-6 alkyl, - C1-6 alkoxy, - C3-7 cycloalkyl, - C3-7 cycloalkyl alkyl C1-6, - C1-6 alkoxycarbonyl, - carboxyl, - carbamoyl, - mono- or di- C 1-6 alkyl carbamoyl, - C1-6 alkoxycarbonyloxy, - mono- or C1-6 alkyl aminocarbonyloxy, - alkylcarbonyloxy C1-20-C1-6 alkyl, - C1-20 alkoxycarbonyloxy-C1-6 alkyl, - arylcarbonyloxy-C1-6 alkyl, wherein said aryl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, C1-6 alkyl, halo C1-6 alkyl, C1-6 alkoxy and halo C1-6 alkoxy； - aminocarbonyloxy-C1-6 alkyl substituted with mono or di-C1-6 alkyl, - aminocarbonyloxy-C1-6 alkyl substituted with aryl, wherein said aryl is optionally substituted with one to three substituents independently selected from the group consisting of halogen, C1-6 alkyl, halo C1-6 alkyl, C1-6 alkoxy and halo C1-6 alkoxy-hydr
