HERMANN, Johannes Cornelius,LOWRIE, JR.,LUCAS, Matthew C.,LUK, Kin-Chun Thomas,PADILLA, Fernando,WANNER, Jutta,XIE, Wenwei,ZHANG, Xiaohu
申请号：
ES12710724
公开号：
ES2588680T3
申请日:
2012.03.26
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula I ** Formula ** wherein, R 1, is phenyl, optionally substituted with one or more C 1-6 alkyl, C 1-6 haloalkyl, hydroxy, C 1-6 hydroxyalkyl, C 1-6 alkoxy, C 1-6 alkyl 6-sulfonyl, halo, nitro, amino, aminoalkyl, amido, cyano, oxo, or R1 '； R1, is heterocycloalkyl or spiroheterocycloalkyl, each of them, optionally substituted with one or more R1 "； R1", is hydroxy, halo, C1-6 alkyl, C1-6 alkoxy, or C1-6 haloalkyl； B, is phenyl, pyridinyl, pyrrolidinyl, or piperidinyl； X. is OH, C1-6 alkoxy, NHC (>； = O) Y, C (>； = O) NH2, C (>； = O) NHY, C (>； = O) X ', C (>； = O) Y , CH2NHY, CH2CH2Y, CF>； = CHY, CH>； = CHY, CH2OH, C (>； = O) NHCH2CH2N (CH3) 2, or C (>； = O) NHCH2CH2Y； X ', is OH or C1-6 alkoxy； And, it is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each of them, optionally substituted with one or more Y3； Y3, is hydroxy, C1-6 alkyl, C1-6 alkoxy, halo, oxo, C1-6 haloalkyl, C1-6 hydroxyalkyl, amino, amido, C (>； = O) NH (CH3), C (>； = O) OH, C (>； = O) OY4, or heteroaryl, optionally substituted by one or more C1-6 alkyl, oxo. or SH； Y4, is C1-6 alkyl； or a pharmaceutically acceptable salt thereof, wherein "heterocycloalkyl" means a cyclic, saturated, monovalent radical consisting of one to two rings, including spirocyclic ring systems, of three to eight atoms per ring, incorporating to one or more ring heteroatoms (chosen from N, O, or S (O) 0-2), and which may be optionally substituted with one or more substituents, selected from hydroxy, oxo, cyano, C1- alkyl 6, C1-6 alkoxy, 6 haloalkoxy C1-, alkylthio, halo, haloalkyl C1-6, hydroxyalkyl, nitro, alkoxycarbonyl, amino, alkylamino, alkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylaminosulfonyl, alkylsulfonylamino, arylsulfonylamino, alkylaminocarbonylaminocarbonylaminocarbonylaminocarbonylcarbonylaminocarbonylcarbonylaminocarbonylcarbonylaminocarbonylcarbonylaminocarbonylcarbonylaminocarbonylcarbonylaminocarbonylcarbonylaminocarbonylcarbonylaminocarbonyl , and ion
