A compound of the formula X ** (See formula) ** in which Z is carbon or nitrogen, R * is H, –R1, –R1 – R2 – R3, –R1 – R3 or –R2 – R3； wherein: R1 is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, and is optionally substituted by C1-6 alkyl, hydroxy, C1-6 alkoxy, halogen, nitro, amino, cyano or halo- C1-6 alkyl, R2 is -C (>； = O), –C (>； = O) O, –C (>； = O) NH, –S (>； = O) 2； O, NR3 or C1-6 alkyl, R3 is H or R4； R4 is C1-6 alkyl, C1-6 alkoxy, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl-heteroaryl, heteroaryl-alkyl, cycloalkyl, alkyl-cycloalkyl, cycloalkyl-alkyl, heterocycloalkyl, alkyl-heterocycloalkyl or heterocycloalkyl-alkyl, and is optionally substituted by C1-6 alkyl, hydroxy, C1-6 alkoxy, halogen, nitro, amino, cyano, C1-6-sulfonyl alkyl, heterocycloalkyl or halo- C1-6 alkyl； R ** is a group of the formula I * or II * X Y (I *) X Y (II *) Q is pyrrolyl, cycloalkyl or cycloalkenyl； X is o-hydroxymethyl； Y is H, –R5 – R6, –R6 or –R5 – R6 – R7； R5 is –NHC (>； = O), –NHC (>； = O) NR5 ’, - (CH2) nC (>； = O) NR5’, –NH or - (CH2) nC (>； = O)； where n is the number 0, 1 or 2； and R5 ’is H, C1-6 alkyl, C1-6 alkoxy or hydroxy-C1-6 alkyl； R6 is C1-6 alkyl, aryl, arylalkyl, alkylaryl, heteroaryl, alkyl-heteroaryl, heteroaryl-alkyl, cycloalkyl, alkylcycloalkyl, cycloalkyl-alkyl, heterocycloalkyl, alkyl-heterocycloalkyl or heterocycloalkyl-alkyl and is optionally substituted by one or more substituents chosen between the group consisting of C1-6 alkyl, hydroxy, halo- C1-6 alkyl, C1-6 alkoxy, halo- C1-6 alkoxy, halogen, nitro, amino, amido, amido-C1-6 alkyl, cyano and trialkylsilyl； and R7 is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, optionally substituted by one or more substituents chosen from the group consisting of C1-6 alkyl, hydroxy, halo- C1-6 alkyl, C1-6 alkoxy, halo- C1-6 alkoxy, halogen, nitro, amino, oxo, cyano and trialkylsilanyl, or is optionally connected to an aryl, heteroaryl, cycloalkyl or heterocycloalkyl ring, so that the two ri
