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氫萘喹啉衍生物
专利权人:
LIMITED;DAIICHI SANKYO COMPANY
发明人:
OHTSUKA, MASAMI,大塚雅己,FUJII, KUNIHIKO,藤井邦彦,藤井邦彥,TSUDA, TOSHIFUMI,津田敏史,DOI, FUMINAO,土居史尙,MIYAUCHI, SATORU,宫内智,宮內智,ISOBE, TAKASHI,矶部崇,磯部崇
申请号:
TW104139057
公开号:
TW201629015A
申请日:
2015.11.25
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The present invention provides a compound represented by general formula (I) which has excellent retinoic acid receptor-related orphan receptor γt inhibitory activity and IL-17 production inhibitory activity, or a pharmaceutically acceptable salt thereof. (In the formula, U represents a phenyl group, pyridyl group, tetrahydrofuryl group, tetrahydropyranyl group or benzyl group which may be independently mono- to tetra-substituted by groups selected from among halogen atoms, C1-C6 alkyl groups and C1-C6 alkoxy groups, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group or the like; R1 represents a hydrogen atom, a halogen atom, a hydroxyl group or the like; R2 represents a hydrogen atom or a C1-C6 alkyl group; R3 represents a hydrogen atom, a halogen atom, a hydroxyl group or the like; R4 represents a hydrogen atom or the like; R5 represents a C1-C6 alkyl group which may be independently mono- to tetra-substituted by groups selected from among a hydroxyl group and C1-C6 alkoxy groups, a hydrogen atom or the like; R6 represents a C1-C6 alkyl group which may be independently mono- or di-substituted by groups selected from among C1-C6 alkylsulfonyl groups and a hydroxyl group, a hydrogen atom, a hydroxyl group or the like; R7 represents a hydrogen atom or a fluorine atom; R8 represents a hydrogen atom, a fluorine atom or the like; R9 represents a hydrogen atom; T represents a single bond, an oxygen atom or a group represented by formula -NH-; Y may be the same or different and each represents a halogen atom or a C1-C6 alkyl group; m represents an integer of 0-3; a saturated ring containing a nitrogen atom may be fused with a cyclopropane ring to form a fused ring; and n represents an integer of 1-3.)本發明提供一種以下述通式(I)表示之化合物或其等藥學上可容許的鹽,其具有優異的視網酸受體相關孤兒受體γt抑制作用及抑制IL-17產生之作用,[式中,U為可獨立地經1至4個選自鹵素原子、C1-C6烷基及C1-C6烷氧基之基取代的苯基、吡啶基、四氫呋喃基、四氫哌喃基或苄基、C1-C6烷基、C1-C6鹵化烷基等;R1為氫原子、鹵素原子、羥基等;R2為氫原子或C1-C6烷基;R3為氫原子、鹵素原子、羥基等;R4為氫原子等;R5為可獨立地經1至4個選自羥基及C1-C6烷氧基之基取代的C1-C6烷基、氫原子等;R6為可獨立地經1至2個選自
来源网站:
中国工程科技知识中心
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