Include Pharmaceutical compositions comprising a compound and also provides Treatment methods, including methods for the treatment of infection by the hepatitis C virus and Methods for the treatment of hepatic fibrosis, the methods generally involve the admi Nistracion to an individual in need of an effective amount of a compound or composition.Claim 1: a compound characterized by the formula (1), (2) or (3), in which: (a) R1 and R2 are independently H each Halo, cyano, Nitro, hydroxyl, alkyl, cycloalkyl C3 C1 - 6, - 7, - 10 alquenilo alquilcicloalquilo C4, C2 alkoxy C1 - 6, 6, 6 hidroxialquilo C1 -, alkyl - or C1 6 Pcionalmente until 5 fluoro substituted with alkoxy optionally substituted C1, with up to 5 - 6 fluoro,Aryl C6 or 10, piridilo, pirimidilo, tienilo, furanilo, thiazolyl, oxazolilo, phenoxy, tiofenoxi, S (OR) 2nr6r7, NHC (OR) nr6r7 nr6r7, NHC (S), C (o) nr6r7, nr6r7, R8, C (o) C (o) 0R8, NHC (R8) NHC 0R8 (, OR), (OR) 2r8 somr8, NHS, chnnr6r7, ochnr6r7, or where ochnr9 R9 is imidazolilo or pirazolilo； these tienilo pyrimid, ILO, furanilo,Oxazolilo thiazolyl and in the definition of R1 and R2 are optionally substituted with two Halo, cyano, Nitro Hydroxy alkyl, cycloalkyl, C1 - C3 - 6, 7, 10 alquenilo alquilcicloalquilo C4, C1 C2 - 6, 6 - alkoxy alkyl hidroxialquilo C1, C1 - 6 - 6, optionally replaced with up to 5 fluoro alkoxy, C1 - 6 optionally replaced with up to 5 or 10 C6 fluoro aryl； these, piridilo,Tiofenoxi phenoxy and in the definition of R1 and R2 are optionally substituted with up to three Halo, cyano, Nitro Hydroxy alkyl, cycloalkyl, C1 - C3 - 6, 7, 10 alquenilo alquilcicloalquilo C4, C1 C2 - 6, 6 - alkoxy alkyl hidroxialquilo C1, C1 - 6 - 6, optionally replaced with up to 5 fluoro alkoxy, C 1 - 6 optionally replaced with up to 5 fluoro； (b) M = 0, 1 or 2； (c) R4 is H, alkyl C1 - 6Cycloalkyl C3 - C4 - 10 7 alquilcicloalquilo, phenyl or benzyl, phenyl or benzyl optionally replaced with up to three Halo, cyano, Nitro Hydroxy alkyl, cycloalkyl, C1
