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Aminopyrimidine derivatives as modulators of LRRK2
专利权人:
F. Hoffmann-La Roche AG
发明人:
BAKER-GLENN, Charles,BURDICK, Daniel Jon,CHAMBERS, Mark,CHAN, Bryan K.,CHEN, Huifen,ESTRADA, Anthony,GUNZNER, Janet L.,SHORE, Daniel,SWEENEY, Zachary Kevin,WANG, Shumei,ZHAO, Guiling
申请号:
ES11724168
公开号:
ES2577829T3
申请日:
2011.06.01
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: m is from 0 to 3; X is: -NRa-; and Ra is hydrogen or C1-6 alkyl; R1 is: C1-6 alkyl; C2-6 alkenyl; C2-6 alkynyl; C1-6 haloalkyl; C1-6 alkoxy-C1-6 alkyl; C2-6 hydroxyalkenyl; C1-6 aminoalkyl; C1-6 alkylsulfonyl-C1-6 alkyl; C3-6 cycloalkyl optionally substituted with C1-6 alkyl; C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; tetrahydrofuranyl; C1-6 tetrahydrofuranylalkyl; oxetanyl; or oxetanalkyl C1-6; or R1 and Ra together with the atoms to which they are attached form a three to six membered ring that may optionally include an additional heteroatom selected from O, N and S, and which is substituted with oxo, halo or C1-6 alkyl; R2 is: halo; C1-6 alkoxy; cyano; C2-6 alkynyl; C2-6 alkenyl; C1-6 haloalkyl; C1-6 haloalkoxy; C3-6 cycloalkyl, wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; tetrahydrofuranyl; C1-6 tetrahydrofuranylalkyl; acetyl; oxetanyl; or oxetanalkyl C1-6; R3 is: -OR4; halo; cyano; C1-6 alkyl; C1-6 haloalkyl; C3-6 cycloalkyl optionally substituted with C1-6 alkyl; C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C 1-6 alkyl; oxetanyl; or oxetanalkyl C1-6; R4 is: C1-6 alkyl; C1-6 haloalkyl; C1-6 alkoxy-C1-6 alkyl; C3-6 cycloalkyl optionally substituted with C1-6 alkyl or halo; C3-6 cycloalkyl-C1-6 alkyl, wherein the C3-6 cycloalkyl portion is optionally substituted with C1-6 alkyl or halo; tetrahydrofuranyl; C1-6 tetrahydrofuranylalkyl; oxetanyl; or oxetanalkyl C1-6; R5 is hydrogen; or C1-6 alkyl; n is 0 or 1; R6 is hydrogen; C1-6 alkyl; C1-6 alkoxy-C1-6 alkyl; C1-6 hydroxyalkyl; C1-6 aminoalkyl; C3-6 cycloalkyl; C3-6 cycloalkyl-C1-6 alkyl; heterocyclyl; or C1-6 heterocyclyl
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