XUE, Chu-Biao,ZHENG, Changsheng,FENG, Hao,XIA, Michael,GLENN, Joseph,CAO, Ganfeng,METCALF, Brian
申请号：
ES05790938
公开号：
ES2614117T3
申请日:
2005.06.27
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: a broken line indicates an optional bond； Wis: ** Formula ** V is N, NO or CR5； X is N, NO or CR2； Y is N, NO or CR3； Z is N, NO or CR4； where no more than one of X, Y and Z is NO； A is O, S, CRCRD, or NRF； RA, RA1, RB and RB1 are each independently H, OH, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, heterocyclyl , carbocyclyl, NR10R12NR10CO2R10NR10CONR10R 12, NR10SO2 NR10R 12, NR10-SO2-R11, CN, CONR10R12CO2R10, NO2, SR10, SOR10, SO2R10, or SO2 -NR10R12； RC and RD are each, independently, H, OH, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 thioalkoxy, heterocyclyl, carbocyclyl, carbocyclyloxy, heterocyclylalkyl, carbocyclylalkyl, NR10R12NR10CO2R11, NR10CONR10R 12, NR10SO2 NR10R12NR10-SO2-R11, CN, CONR10R12CO2R10, NO2, SR10, SOR10, SO2R10 or SO2 -NR10R12, wherein said C1-6 alkyl is optionally substituted with 1-5 substituents independently selected from hydrox OH , C1-6 alkoxy, and C1-6 haloalkyl, and wherein said heterocyclyl, carbocyclyl, carbocyclyloxy, heterocyclylalkyl, and carbocyclylalkyl are each optionally substituted with 1-4 substituents independently selected from C1-6 alkyl, C2-6 alkenyl, alkynyl C2-6, halo, C1-4 haloalkyl, CN, NO2, OR13, SR13, C (O) R14, C (O) OR13, C (O) NR15R16, NR1R16 NR15CONHR16, NR15C (O) R14, NR15C (O) OR13, S (O) R14, S (O) 2R14, S (O) NR15R16 and SO2 NR15R16； RF is H, OH, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, heterocyclyl, carbocyclyl, carbocyclyloxy, heterocyclylalkyl, carbocyclylalkyl, SOR10, SO2R10, or SO2-NR10R12, wherein said alkyl C1-6 is optionally substituted with 1-5 substituents independently selected from hydroxyl, OH, C1-6 alkoxy, and C1-6 haloalkyl, and wherein said heterocyclyl, carbocyclyl, carbocyclyloxy, heterocyclylalkyl, and carbocyclylalkyl are optionally substituted with 1 -4 substituents independently selected from
