MANGION, IAN,CARTER, PERCY,DUAN, JINGWU,TEBBEN, ANDREW J.
申请号：
ES11704004
公开号：
ES2449379T3
申请日:
2011.02.08
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I): ** Formula ** or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: X is O or CH2； W is an NR2R3 or a 3-20 member nitrogen-containing ring, in which the ring (i) is attached by the nitrogen atom, (ii) may optionally contain 1-4 heteroatoms selected from N, O and S and ( iii) this optionally substituted with one or more R10a； m is 1-4； n is 0-2； R1 is H or alkyl； R2 is H, alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl, wherein the cycloalkyl, aryl, heteroaryl or heterocyclyl may be optionally substituted with one or more R9a； R3 is H, alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl, wherein the cycloalkyl, aryl, heteroaryl or heterocyclyl may be optionally substituted with one or more R9a； R6, at each occurrence, is independently selected from halo, alkyl, haloalkyl, haloalkoxy and aryloptionally substituted with halo； R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, halo, -CN, -NO2, -C (>； = O) OR14, -OCF3, -OR14,>； = O, - NR14R14 or arylalkyl； R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, halo, -CN, -NO2, -C (>； = O) OR14, -OCF3, -OR14,>； = O, - NR14R14 or arylalkyl, wherein the aryl, cycloalkyl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a； R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl heterocyclyl, in which the alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may optionally be substituted with 0-3 R14a； R14a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, halo, -CN, -NO2, -C (>； = O) OR24, -OCF3, -OR24,>； = O, - NR24R24 or arylalkyl； and R24, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl heterocyclyl； wherein, in the above definitions, "alkyl" refer
