The present invention relates to bisaryl (thio)morpholine derivatives of the formula (I)wherein RI is an aryl substitutent selected from phenyl, pyridyl, pyrimidinyl, biphenyl and naphthyl, each optionally substituted with one or more substituents independently selected from halogen, (1-6C)alkyl optionally substituted with one or more fluoro atoms, (1-4C)alkoxy optionally substituted with one or more fluoro atoms, amino, di(1-4C)alkylamino, -SO2-(1-4C)alkyl, -CO-(1-4C)alkyl, -CO-O-(1-4C)alkyl and -NH-CO-(1-4C)alkyl, or substituted with phenoxy, benzyl, benzyloxy, phenylethyl or morpholinyl, each optionally substituted with (1-4C)alkyl, and (8-10C)bicyclic group, bicyclic heterocycle, each optionally substituted with (1-4C)alkyl optionally substituted with one or more fluoro atoms or oxo A is selected from -CO-, -NH-, -0-, -5-, -SO- or -SO2- ring structure B optionally contains one nitrogen atom R2 is H, (1-4C)allkyl optionally substituted with one or more fluoro atoms, (1-4C)alkoxy optionally substituted with one or more fluoro atoms, or halogen and R3 is (1-4C)alkylene-R6 wherein the alkylene group may be substituted with (CH2)2 to form a cyclopropyl moiety or with one or more halogen atoms, or R3 is (3-6C)cycloalkylene-R5 or -CO-CH2-R6, wherein R6 is -OH, -P03H2, -OPO3H2, -000H, -COO(1-4C)alkyl or tetrazol-5-yl R4 is H or (1-4C)alkyl R5 is one or more substituents independently selected from H, (1-4C)alkyl or oxo W is -0-, -S-, -SO- or -SO2- or a pharmaceutically acceptable salt, a solvate or hydrate thereof, with the proviso that the derivative of formula (I) is not 2-[4-(4-chlorophenoxy)-2-chloro-phenyl]-4morpholineethanol.The compounds of the invention have affinity to SIP receptors and may be used in the treatment, alleviation or prevention of SIP receptor mediated diseases and conditions.本發明涉及式(I)的雙芳基(硫代)嗎啉衍生物,或其藥學上可接受的鹽、溶劑合物或水合物,其中R1為選自下列的芳基取代基:苯基,吡啶基,嘧啶基,聯苯基和萘基,各自任選地被一個或多個獨立地選自鹵素、任選地被一個或多個氟原子取代的(1-6C)烷基、任選地一個或多個被氟原子取代的(1-4C)烷氧基、氨基、二(1-4C)烷基氨基、-SO2-(1-4C)烷基、
