The present invention relates to logical formula (I)s [in formula, Ar1 indicates to can have the aryl or heteroaryl ring group of substituent group, R1 expressions can be with substituted low alkyl group, low-grade alkenyl, low-grade alkynyl or low-grade cycloalkyl, or indicate can have the aryl of substituent group, aralkyl or heteroaryl ring group, R2 indicates hydrogen atom, low alkyl group, low-grade alkenyl or low-grade alkynyl, or indicate can have the aryl of substituent group, aralkyl or heteroaryl ring group, R3 indicates hydrogen atom or low alkyl group, R4 indicates hydrogen atom, halogen atom, hydroxyl, group shown in low alkyl group or-N (R1k) R1m, T and U indicates nitrogen-atoms or methine] compound represented etc.. The compound of the present invention has excellent Weel kinase inhibitory activities by what, is useful in the field of drug field, particularly various treatments of cancer.本發明涉及通式(I)[式中，Ar1表示可以具有取代基的芳基或雜芳環基，R1表示可以被取代的低級烷基、低級烯基、低級炔基或低級環烷基，或表示可以具有取代基的芳基、芳烷基或雜芳環基，R2表示氫原子、低級烷基、低級烯基或低級炔基，或表示可以具有取代基的芳基、芳烷基或雜芳環基，R3表示氫原子或低級烷基，R4表示氫原子、鹵原子、羥基、低級烷基或-N(R1k)R1m所示的基團，T和U表示氮原子或次甲基]所示的化合物等。本發明的化合物由於具有優異的Weel激酶抑制作用，在藥物領域、特別是各種癌症治療的領域中是有用的。
