This invention relates to novel amino acid derivatives of formula (I) wherein the R groups have the following meanings: -R1 is -H or -(1-4C)alkyl； -R2 is -C(O)R15 or -S(O)2R15； -R3 is -H, -(1-4C)alkyl or -OR16； -R4 is -H, -(1-4C)alkyl or -OR16； -R6 is -H or -C(R16)NOR16； -R7 is -H, -halogen, -cyano； -(1-6C)alkyl, -(2-6C)alkenyl or -(2-6C)alkynyl, all optionally substituted with -amino, -hydroxyl or -halogen； -R8 is -H, -cyano, -halogen, -nitro； -(1-6C)alkyl, -(2-6C)alkenyl, -(2-6C)alkynyl or -O(1-6C)alkyl, all optionally substituted with -amino, -hydroxyl or -halogen； -(hetero)aryl, optionally substituted with -cyano, -halogen, -(1-4C)alkyl, -(1-4C)alkoxy, -(1-4C)alkoxy(1-4C)alkyl or -(hetero)aryl； -C(R16)NOR16； -C(O)N(R17)2； -C(O)R18, -C(O)OR19, -NHC(O)R20, or -NHS(O)2R21； -R9 is -H, -halogen, -cyano, or -(1-4C)alkyl, optionally substituted with -halogen； -R10 is -H or -(1-4C)alkyl； -R11 is -H； -R12 is -H, -cyano or -(1-4C)alkyl； -R13 is -H, -(1-4C)alkyl, -halogen or -formyl； -R14 is -H, -halogen, -cyano, -(1-4C)alkyl or -(hetero)aryl； or a pharmaceutically acceptable salt thereof. The compounds of this invention are highly specific for the glucocorticoid receptor and may be used for treating inflammatory diseases.本發明係關於式I所示之新穎胺基酸衍生物或彼等之藥學上可接受的鹽類，；式I；其中R基團具有下列定義：－R1示－H或－(C1－4)烷基；－R2示－C(O)R15或－S(O)2R15；－R3示－H、－(C1－4)烷基或－OR16；－R4示－H、－(C1－4)烷基或－OR16；－R6示－H或－C(R16)NOR16；－R7示－H、－鹵素、－氰基、－(C1－6)烷基、－(C2－6)烯基或－(C2－6)炔基，彼等皆任意經－胺基、－羥基或－鹵素所取代；－R8示－H、－氰基、－鹵素、－硝基、－(C1－6)烷基、－(C2－6)烯基、－(C2－6)炔基或－O(C1－6)烷基，彼等皆任意經－胺基、－羥基或－鹵素所取代；－(雜)芳基，其任意經－氰基、－鹵素、－(C1－4)烷基、－(C1－4)烷氧基、－(C1－4)烷氧基(C1－4)烷基或－(雜)芳基所取代；－C(R16)NOR16；－C(O)N(R17)2；－C(O)R18、－C(O)OR19；－NHC(O)R20或－NHS(O)2R21；－R9示－H、－鹵素、－氰基、或任意經－鹵素所取代的－(C1－4)烷基；－R10示－H或－(C1－4)烷基；－R11示－H；－R12示－H、－氰基或－(C1－4)烷基；－R13示－H、－(C1－4)烷基、－鹵素或－甲醯基；－R14示－H、－鹵素、－氰基、－(C1－4)烷基或－(雜)芳基；－R15示－H；－(C1－6)烷基、－(C2－C6)烯基、－(C2－C6)炔基、－O(C2－6)烷基、－O(C2－6)烯基或－O(C2－6)炔基，彼等皆任意經一或多個－OH、－鹵素、－氰基或－(雜)芳基所取代；－(雜)芳基，其任意經－(C1－4)烷基、－鹵素或－NH2所取代；－NH2；－(二)(C1－4)烷基胺基；－(C1－4)烷硫基(C1－4)烷基或－(C1－
