The present invention is directed to aziridinyl epothilone compounds as further described herein, and/or pharmaceutically-acceptable salts and/or solvates thereof having the following Formula:wherein K is -O-, -S-, or -NR7-； A is -(CR8R9)-(CH2)m-Z- wherein Z is -(CHR10)-, -C(=O)-, -C(=O)-C(=O)-, -OC(=O)-, -N(R11)C(=O)-, -SO2-, or -N(R11)SO2-； B1is hydroxyl or cyano and R1is hydrogen or B1and R1are taken together to form a double bond； R2,R3, and R5are, independently, hydrogen, alkyl, substituted alkyl, aryl or substituted aryl； or R2and R3may be taken together with the carbon to which they are attached to form an optionally substituted cycloalkyl； R4is hydrogen, alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, or substituted aryl； R6is hydrogen, alkyl or substituted alkyl； R7, R8, R9,R10, R11and R12are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, or substituted heteroaryl； and R13is aryl, substituted aryl, heteroaryl or substituted heteroaryl.本發明係關於具有下式如在本文中進一步描述之吖丙啶基－埃坡黴素化合物及/或其醫藥學上可接受之鹽及/或溶劑合物：其中K為－O－、－S－或－NR7－；A為－(CR8R9)－(CH2)m－Z－，其中Z為－(CHR10)－、－C(＝O)－、－C(＝O)－C(＝O)－、－OC(＝O)－、－N(R11)C(＝O)－、－SO2－或－N(R11)SO2－；B1為羥基或氰基且R1為氫，或B1與R1一起形成一雙鍵；R2、R3及R5獨立地為氫、烷基、經取代之烷基、芳基或經取代之芳基；或R2與R3可與其所連接之碳一起形成視情況經取代之環烷基；R4為氫、烷基、烯基、經取代之烷基、經取代之烯基、芳基或經取代之芳基；R6為氫、烷基或經取代之烷基；R7、R8、R9、R10、R11及R12獨立地為氫、烷基、經取代之烷基、環烷基、經取代之環烷基、芳基、經取代之芳基、雜環烷基、經取代之雜環烷基、雜芳基或經取代之雜芳基；且R13為芳基、經取代之芳基、雜芳基或經取代之雜芳基。
