Nawaz Mohammed Khan;Geoff Lawton;Meriel Ruth Kimberly;Kanesalingam Suthaharan;Simon David Edwards
发明人:
Simon David Edwards,Meriel Ruth Kimberly,Kanesalingam Suthaharan,Nawaz Mohammed Khan,Geoff Lawton
申请号：
US12746524
公开号：
US20120065270A1
申请日:
2008.12.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of formula (I) and pharmacologically acceptable salts and pro-drugs wherein:Ar1 and Ar2=aryl or heteroaryl；a=0 to 5；R1=alkyl, halogen, haloalkyl, alkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino and cyano and, where a is >；1, each R1 is the same or different；b=0 to 5；R2=alkyl, halogen, haloalkyl, alkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino and cyano and where b is >；1, each R2 is the same or different；V=(CR3aR3b)pSO2N(R3b)X and (CR3aR3b)pN(R3b)SO2(X)；W=NR4a, O, S, S═O, SO2 and C(R4aR4b)2；X=hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, aryloxyalkyl, polyalkylene glycol residues, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl and alkyl groups substituted with ≧1 NR8R9 groups wherein R8 and R9+nitrogen atom form a saturated or partially unsaturated heterocyclic group which is optionally further substituted by ≧1 substituents selected from alkyl, halogen, haloalkyl, alkoxy, alkoxycarbonyl, carboxyl, nitro, amino, monoalkylamino, dialkylamino and hydroxyl；Y and Z each ═(CR5aR5b)n1, C═O, SO2, C(═O)NR5a, C(═O)NR5aSO2 or C═O(R5aR5b)n2；R3a, R3b, R4a, R4b, R5a and R5b each=hydrogen, alkyl, cycloalkyl, aryl or heteroaryl；n1 and n2 each =0 to 2； andp=0 to 2；are excellent selective modulators of potassium ion flux through KCNQ2, KCNQ3 and/or KCNQ2/3 channels, making them of use in treating and preventing a number of conditions including pain and lower urinary tract disorders.
