BAGDANOFF, Jeffrey T.,DING, Yu,HAN, Wooseok,HUANG, Zilin,JIANG, Qun,JIN, Jeff Xianming,KOU, Xiang,LEE, Patrick,LINDVALL, Mika,MIN, Zhongcheng,PAN, Yue,PECCHI, Sabina,PFISTER, Keith Bruce,POON, Daniel
申请号：
ES14800191
公开号：
ES2684360T3
申请日:
2014.10.29
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is an optionally substituted group selected from C3-8 cycloalkyl, 5-8 membered heterocyclyl containing 1-2 selected heteroatoms of N, O and S as ring members, phenyl, -SO2-phenyl, -C (O) -phenyl, -C (R8) 2-phenyl, and 5-6 membered heteroaryl ring, wherein said heterocyclyl and heteroaryl contain 1-2 heteroatoms selected from N, O and S as ring members, and where the optional substituents for R1 are 1-3 groups independently selected from D, halo, hydroxy, amino, -N (R8) 2, CN, C1- 4 alkyl, C1-4 alkoxy, -S (C1-4 alkyl), C1-4 haloalkyl, C1-4 haloalkoxy, C3-6 cycloalkyl, 3-6 membered heterocyclyl containing 1-2 heteroatoms selected from N, O and S, oxo (except in aromatic rings), COOR8, CON (R8) 2, -NR8-C (O) R8, -NR8-C (O) OR8 -SO2R8, -NR8SO2R8, and SO2N (R8) 2, where each R8 is independently H or C1-4 alkyl； L is ** Formula ** where R "is methyl or ethyl, and is optionally substituted with fluorine, amino, hydroxy, methylamino, ethylamino, dimethylamino, -OP (O) (OH) 2, methoxy or ethoxy； X and Y are independently selected from H, D, halo, CN, amino, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and C1-4 haloalkoxy； R2 is H, C1-4 alkyl, or aryl- C1-2-alkyl-, where the aryl and C1-4 alkyl are optionally substituted with halo, CN, C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, or C1 -4 alkylsulfonyl； or R2 and L join together to form a heterocyclic group selected from morpholine, piperidine, thiomorpholine, piperazine and pyrrolidine which is linked to R1 and is also optionally substituted with one or two groups independently selected from C1- 4 alkyl, C1-4 alkoxy, oxo, CN, COOR7, CON (R7) 2, and -SO2R7； where each R7 is independently H or C1-4 alkyl； Z is N or CR4； R4 is H, D, halo, C1-4 alkyl, C1-4 haloalkyl, or C1-4 alkoxy； R5 is selected from -C (O) -R5a and R5a； where R5a is an optionally substituted group C3-8 cycloalkyl, C3-8 cyc
