LEONARD, Kristi A.,BARBAY, Kent,EDWARDS, James P.,KREUTTER, Kevin D.,KUMMER, David A.,MAHAROOF, Umar,NISHIMURA, Rachel,URBANSKI, Maud,VENKATESAN, Hariharan,WANG, Aihua,WOLIN, Ronald L.,WOODS, Craig R.
申请号：
ES13818857
公开号：
ES2628365T3
申请日:
2013.10.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compounds of Formula 1: ** Formula ** wherein: R 1 is pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, pyridyl, pyridyl N-oxide, pyrazinyl, pyrimidinyl, pyridazyl, piperidinayl, quinazolinyl, cinolinyl, benzothiazolyl, indazolyl, indazolyl, indazolyl , tetrahydrofuranyl, furanyl, phenyl, oxazolyl, isoxazolyl, thiophenyl, benzoxazolyl, benzimidazolyl, indolyl, thiadiazolyl, oxadiazolyl or quinolinyl； wherein said pyridyl, pyridyl N-oxide, pyrazinyl, pyrimidinyl, pyridazyl, piperidinayl, quinazolinyl, cinolinyl, benzothiazolyl, indazolyl, imidazolyl, phenyl, thiophenyl, benzoxazolyl, benzimidazolyl, indolyl, quinolinyl optionally, and substituted pyrazyl O ( ) C (1-4) alkyl, C (O) NH2, C (O) NHC (1-2) alkyl, C (O) N (C (1-2) alkyl) 2, NHC (O) C (1 -4) allyl, NHSO2C (1-4) alkyl, C (1-4) alkyl, CF3, CH2CF3, Cl, F, -CN, OC (1-4) alkyl, N (C (1-4) alkyl) 2, (CH2) 3OCH3, SC (1-4) alkyl, OH, CO2H, CO2C (1-4) alkyl, C (O) CF3, SO2CF3, OCF3, OCHF2, SO2CH3, SO2NH2, SO2NHC (1-2) alkyl , SO2N (C (1-2) alkyl) 2, C (O) NHSO2CH3, or OCH2OCH3； and optionally substituted with up to two additional substituents independently selected from the group consisting of Cl, C (1-2) alkyl, SCH3, OC (1-2) alkyl, CF3, -CN, and F； and wherein said triazolyl, oxazolyl, isoxazolyl, pyrrolyl, and thiazolyl are optionally substituted with up to two substituents independently selected from the group consisting of SO2CH3, SO2NH2, C (O) alkyl NH2, -CN, OC (1-2), (CH2) (2-3) OCH3, SCH3, CF3, F, Cl, and C (1-2) alkyl； and said thiadiazolyl and oxadiazolyl are optionally substituted with C (1-2) alkyl； and said pyridyl, pyridyloxide, pyrimidinyl, pyridazyl, and pyrazinyl are optionally substituted with up to three additional substituents independently selected from the group consisting of C (O) NHC (1-2) alkyl, C (O) N (C (1-2) ) alkyl) 2, NHC (O) C (1-4) alkyl, NHSO2C (1-4) alkyl, C (O) CF3, SO2CF3, SO2NHC (1-2) alkyl, SO2N (C (1-2) alkyl ) 2, C (O) NHSO2CH3, SO2CH3, SO2NH2, C (O) NH2, -35 CN, OC (1-
