CORKEY, Britton Kenneth,ELZEIN, Elfatih,JIANG, Robert H.,KALLA, Rao V.,KOBAYASHI, Tetsuya,KOLTUN, Dmitry,LI, Xiaofen,MARTINEZ, Ruben,NOTTE, Gregory,PARKHILL, Eric Q.,PERRY, Thao,ZABLOCKI, Jeff,VENKATA
申请号：
ES12722595
公开号：
ES2648820T3
申请日:
2012.05.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula IA: ** Formula ** in which: Y is -C (O) -； X1 is C (R3) 2 and X2 is -O-, and the dotted line is a single link； Q is a covalent bond； R1 is C3-6 cycloalkyl, C3-6 cycloalkenyl or aryl； wherein said C3-6 cycloalkyl, C3-6 cycloalkenyl or aryl are substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, CN, - SF5, -Si (CH3) 3, -O -R20, -S- R20, -C (O) -R20, -C (O) -OR20, -N (R20) (R22), -C (O) -N (R20) (R22), -N ( R20) -C (O) -R22, -N (R20) -S (O) 2-R22, -S (O) 2-R20, - S (O) 2-N (R20) (R22), alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl and heterocyclyl； and wherein said C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl or heterocyclyl optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2 , aryl, heterocyclyl, heteroaryl, C1-4 alkyl, C3-6 cycloalkyl, - N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N ( R20) (R22), -CN and -O-R20； R2 is -R6, -C1-6-R6 alkylene, -C2-6-R6 alkylene, -C2-6-R6 alkylene, -L-R6, -L-C1-6-R6 alkylene, -C1-6 alkylene L-R6 or -C1-6-L-C1-6-R6 alkylene； L is -O-, -S-, -C (O) -, -S (O) 2-, -NR20S (O) 2-, -S (O) 2NR20-, -C (O) NR20- or - NR20C (O) -； each R3 is independently hydrogen, C1-6 alkyl, C3-6 cycloalkyl, aryl, heteroaryl or heterocyclyl； wherein said C1-6 alkyl is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, C3-6 cycloalkyl, aryl, heterocyclyl, heteroaryl, -N (R20) (R22), - C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22), -CN and -O-R20； wherein said C3-6 cycloalkyl, aryl, heterocyclyl and heteroaryl are optionally further substituted with one, two or three substituents independently selected from the group consisting of halogen, -NO2, C1-6 alkyl, aralkyl, C3-6 cycloalkyl, aryl, heterocyclyl, heteroaryl, - N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20) (R22
