CORKEY, Britton Kenneth,ELZEIN, Elfatih,JIANG, Robert H.,KALLA, Rao V.,KOLTUN, Dmitry,LI, Xiaofen,MARTINEZ, Ruben,PARKHILL, Eric Q.,PERRY, Thao,ZABLOCKI, Jeff,VENKATARAMANI, Chandrasekar,GRAUPE, Micha
申请号：
ES12735402
公开号：
ES2583415T3
申请日:
2012.06.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula II: ** Formula ** in which: m is 0, 1 or 2； n is 0, 1, 2 or 3； R2 is C1-6-R5 alkylene, C1-6-L-R5 alkylene or C1-6-L-alkylene C1-6-R5 alkylene； L is -O-, -C (O) -, -NHS (O) 2-, -S (O) 2NH-, -C (O) NH- or -NHC (O) -； each R3 is independently hydrogen, deuterium or C1-6 alkyl； each R4 is independently hydrogen, deuterium or C1-6 alkyl； R5 is cycloalkyl, aryl, heteroaryl or heterocyclyl； wherein said cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of C1-6 alkyl, halo, cycloalkyl, heterocyclyl, heteroaryl, -N (R20) (R22), -C (O) -OR20, -CN and -O-R20； wherein said C1-6 alkyl or heteroaryl are optionally further substituted with one, two or three substituents independently selected from the group consisting of halo, C1-6 alkyl and aryl； and wherein said C1-6 alkyl is optionally further substituted with one, two or three halo； each R10 is independently selected from the group consisting of halo, -NO) 2, -CN, -SF5, -Si (CH3) 3, -OR20, -S-R20, -C (O) -R20, -C ( O) -OR20, -N (R20) (R22), -C (O) -N (R20) (R22), -N (R20) -C (O) -R22, -N (R20) -C (O ) -OR22, - N (R20) -S (O) 2-R26, -S (O) 2-R20, -OS (O) 2-R20, -S (O) 2-N (R20) (R22) , C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl； wherein said C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, aryl, heterocyclyl, heteroaryl, C1-6 alkyl, C1-3 haloalkyl, cycloalkyl, -N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20 ) (R22), -CN and -O-R20； R17 is halo, or C1-6 alkyl； R20 and R22 are each independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl； wherein C1-6 alkyl, C2-6 alkenyl, C1-6 alkynyl, cycloalkyl, hete
