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Quinolines and related analogues as sirtuin modulators
- 专利权人:
- GlaxoSmithKline LLC
- 发明人:
- VU, Chi,DISCH, Jeremy,SPRINGER, Stephanie,BLUM, Charles,PERNI, Robert
- 申请号：
- ES09739775
- 公开号：
- ES2586459T3
- 申请日:
- 2009.04.30
- 申请国别(地区):
- ES
- 年份:
- 2016
- 代理人:
- 摘要：
- A compound represented by the formula: ** Formula ** or a salt thereof, wherein: each of Z11, Z12, Z13 and Z14 is independently selected from N and CR, where R is selected from hydrogen, halo, - OH, -C≡N, C1-C2 alkyl substituted by fluoro, -O- (alkyl substituted by C1-C2 fluoro), -S- (alkyl substituted by C1-C2 fluoro), C1-C4 alkyl, - (C1 alkyl -C2) -N (R14) (R14), -O-CH2CH (OH) CH2OH, -O-(C1-C4) alkyl, -O (C1-C3) alkyl -N (R14) (R14), -N ( R14) (R14), -S-(C1C4) alkyl and C3-C7 cycloalkyl； Y is selected from N and CR13, wherein R13 is selected from hydrogen, halo, -C1-C4 alkyl, -O- (C1-C4 alkyl) and -O- (alkyl substituted by C1-C2 fluoro)； no more than two of Z11, Z12, Z13, Z14 and Y are N； X is selected from-NH-C (>； = O) - †, -C (>； = O) -NH- † -, -NH-C (>； = S) - †, -C (>； = S) -NH - †, -NH-S (>； = O) - †, -S (>； = O) -NH- †, - S (>； = O) 2-NH- †, -NH-S (>； = O) 2 - † -, -NH-S (O) 2-NR15- †, -NR15-S (O) 2-NH- †, -NH-C (>； = O) O- †, OC (>； = O) - NH- †, -NH-C (>； = O) NH- †, -NH-C (>； = O) NR15- †, -NR15-C (>； = O) NH- †, -NH-NR15- †, -NR15-NH- †, -O-NH- †, -NH-O- †, -NH-C (>； = NR15) - †, -C (>； = NR15) - NH- †, -C (>； = O) -NH-CR15R16- †, -CR15R16-NH-C (O) - †, -NH-C (>； = S) -CR15R16- †, -CR15R16-C (>； = S) -NH- †, - NH-S (O) -CR15R16- †, -CR15R16-S (O) -NH- †, -NH-S (O) 2-CR15R16- †, -CR15R16-S (O) 2-NH- †, - NH-C (>； = O) -O-CR15R16- †, -CR15R16-OC (>； = O) - NH- †, -NH-C (>； = O) -NR14-CR15R16- †, -NH-C ( >； = O) -CR15R16- † and -CR15R16-NH-C (>； = O) -O- †, where † represents where X is attached to R11 and: R15 and R16 are independently selected from hydrogen, C1- alkyl C4, CF3 and - (C1-C4 alkyl) -CF3； R11 is selected from a carbocycle and a heterocycle, wherein R11 is optionally substituted by one to two substituents that are independently selected from halo, -C≡N, C1-C4 alkyl, C3-C7 cycloalkyl, C1-C4 fluoro substituted alkyl ,>； = O, -O-R14, -S-R14, - (C1-C4 alkyl) -N (R14) (R14), -N (R14) (R14), -O- (C2-C
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
