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Phenyl azetidinyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
专利权人:
Incyte Holdings Corporation
发明人:
YAO, Wenqing,BURNS, David M.,ZHUO, Jincong
申请号:
ES12735369
公开号:
ES2560611T3
申请日:
2012.06.19
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of the formula I: ** Formula ** or a pharmaceutically acceptable salt thereof; where: X is N or CR4; W is N or CR6; Y is No. CR7; R 1 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-3 alkyl, heterocycloalkyl having 4-6 members, heterocycloalkyl having 4-6 members-C 1-3 alkyl; wherein said C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-3 alkyl, heterocycloalkyl having 4-6 members, and heterocycloalkyl having 4-6 members-C1-3 alkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from fluorine, -OH, -O (C1-3 alkyl), -CN, -CF3, C1-3 alkyl, -NH2, -NH (C1-3 alkyl), - N (C1-3 alkyl) 2, -C (O) N (C1-3 alkyl) 2, -C (O) NH (C1-3 alkyl), -C (O) NH2, -C (O) O ( C1-3 alkyl), -S (O) 2 (C1-3 alkyl), - S (O) 2 (C3-6 cycloalkyl), -C (O) (C3-6 cycloalkyl), and -C (O) (C1-3 alkyl); R2 is H or C1-3 alkyl; wherein said C1-3 alkyl is optionally substituted by 1, 2 or 3 substituents independently selected from fluoro, -OH, -O (C1-3 alkyl), -CN, -CF3, NH2, -NH (C1-3 alkyl), and -N (C1-3 alkyl) 2; or R1 and R2 together with the nitrogen atom to which they are attached forms a heterocycloalkyl having a 4-, 5-, or 6-membered ring; which is optionally substituted with 1, 2 or 3 substituents independently selected from -OH, -O (C1-3 alkyl), -CN, C1-3 alkyl, C1-3 haloalkyl, -NH2, -NH (C1-3 alkyl ), -N (C1-3 alkyl) 2, and -CH2CN; R3 is H, F, Cl, -CN, C1-3 alkyl, -OCF3, -CF3, or -O (C1-3 alkyl); R4 is H, F, Cl, -CN, C1-3 alkyl, or -O (C1-3 alkyl); R5 is H, F, Cl, -CN, C1-3 alkyl, or -O (C1-3 alkyl); R6 is H, F, Cl, -CN, or C1-3 alkyl; and R7 is H, F, Cl, -CN, C1-3 alkyl, -CH2CN, -C (O) N (C1-3 alkyl) 2, -C (O) NH (C1-3 alkyl), or -C (O) NH2.Un compuesto de la fórmula I: **Fórmula** o una de sus sales farmacéuticamente aceptables; donde: X es N o CR4; W es N o CR6; Y es N o CR7; R1 es alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-6, Cicloalquilo C3-6-alquilo C1-3, heterocicloalquilo que tiene 4-6 miembros, heterocicloalquilo
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