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Analogues of 4h-pyrazolo [1,5-¿A] benzimidazole compounds as PARP inhibitors
专利权人:
Humanwell Healthcare (Group) Co., Ltd.;Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.
发明人:
DING, Zhaozhong,CHEN, Shuhui,LI, Gang,WANG, Cailin,ZHANG, Zhibo,TU, Ronghua,YUE, Yang,CHEN, Hailiang,SUN, Wenjie,HUANG, Lu
申请号:
ES15777444
公开号:
ES2754590T3
申请日:
2015.03.30
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, ** Formula ** wherein, D is selected from the group consisting of -C (Rd1) (Rd2) - and -N (Rd4) -; R1-3, Rd1, and Rd2 are separately and independently selected from the group consisting of H, F, Cl, Br, I, CN, OH, SH, and NH2, or are selected from the group, optionally substituted with R01, which Consists of (C1-10) alkyl, (C1-10) heteroalkyl, (C3-10) cyclohydrocarbyl, (C3-10) heterocyclohydrocarbyl (C3-10) alkyl substituted by (C3-10) cyclohydrocarbyl, or (C3-10) heterocyclohydrocarbyl and (C1-10) heteroalkyl substituted with cyclohydrocarbyl (C3-10) or heterocyclohydrocarbyl (C3-10); R01 is selected from the group consisting of F, Cl, Br, I, CN, OH, SH, NH2, and R02; R02 is selected from the group consisting of (C1-10) alkyl, (C1-10) alkyl, N, N-di ((C1-10) alkyl) amino, (C1-10) alkyloxy, (C1-10 alkyl) ) acyl, C1-10alkyloxycarbonyl, (C1-10alkyl) sulfonyl, (C1-10alkyl) sulfinyl, (C3-10) cycloalkyl, (C3-10) cycloalkyl amino, (C3-10) heterocycloalkyl amino, (C3-10) cycloalkyloxy, cyclo (C3-10) alkyl acyl, cycloalkyl (C3-10) carbonyl, cycloalkyl (C3-10) sulfonyl, and cycloalkyl (C3-10) sulfinyl; Heteroatom or heteroaromatic group is independently and separately selected from the group consisting of -C (= O) N (Rd3) -, -N (Rd4) -, -C (= NRd5) -, -S (= O) 2 N (Rd6) -, -S (= O) N (Rd7) -, -O-, -S-, -C (= O) O-, -C (= O -, -C (= S) - , -S (= O) -, and / or -S (= O) 2-; Rd3-d7 are selected independently and separately from the group consisting of H, and R03; R03 is selected from the group consisting of C1-10alkyl, C1-10alkyl acyl, (C1-10alkyloxycarbonyl, (C1-10alkyl) sulfonyl, (C1-10alkyl) sulfinyl, (C3-10) cycloalkyl, C3- 10) acyl, (C3-10) cycloalkyloxy carbonyl, (C3-10) cycloalkyl sulfonyl, and (C3-10) cycloalkyl sulfinyl; R02, and R03 are optionally substituted with R001; R001 is selected from the group consisting of F, Cl , Br, I, CN, OH, N (CH3) 2, NH (CH3), NH2, CF3, (NH2) CH2, (HO) CH2, CH3, CH
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