The invention provides compounds according to Formula (1) which are useful in treating bacterial biofilms, as well as compositions comprising compounds according to Formula (1) and one or more antibiotics, as well as medical devices comprising compounds according to Formula (1):whereinD1 and D2 are independently selected from -H, -OH, -COOR1, -F, -Cl, Br, -O-C1-6-alkyl,-CN, -CF3, -SH, -NR1R2, a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, and a 5-10 membered aromatic hetero- or non-hetero mono- or bicyclic group,wherein the C1-C22 alkyl group, the C2-C22 alkenyl group, and the C2-C22 alkynyl group is optionally substituted with 1 to 5 substituents independently selected from =O, -OH, - COOR1, -F, -Cl, Br, -O-C1-6-alkyl, -O-C2-6-alkenyl, -CN, -CF3, -SH, -NR1R2, and phenyl, wherein said phenyl is optionally substituted with 1 to 3 substituents selected from =O, -OH, - COOR1, -F, -Cl, Br, -C1-6-alkyl, -C2-6-alkenyl, -O-C1-6-alkyl, -O-C2-6-alkenyl, -CN, -CF3, -SH and -NR1R2,wherein the 5-10 membered aromatic group is optionally substituted with 1 to 5 substituents independently selected from =O, -OH, -COOR1, -F, -Cl, -Br, -C1-6-alkyl, -C2-6-alkenyl, -O-C1-6-alkyl, -O-C2-6-alkenyl, -CN, -CF3, -SH, -NR1R2, and phenyl, wherein said phenyl is optionally substituted with 1 to 3 substituents selected from =O, -OH, -COOR1, -F, -Cl, -Br, -C1-6-alkyl, -C2-6-alkenyl, -O-C1-6-alkyl, -O-C1-6-alkenyl, -CN, -CF3, -SH and -NR1R2,wherein R1 and R2 in the above definitions are independently selected from H and C1-6-alkyland with the proviso that at least one of D1 and D2 is a 5-10 membered aromatic group substituted with one or more -OH groups and/or one or more -COOH groupsand wherein L1 and L2 represent the bonds by which D1 and D2 are connected to the tetrahydrofuran rings, with L1 and L2 being independently selected from a direct single or direct double bond, an ester bond, an amide bond, an ether bond, a ketoester bond (i.e. α-ketoester, β-ketoester), a carba
