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INHIBITEURS SELECTIFS DE LA KINASE AURORA A
专利权人:
UNIVERSITAT BERN
发明人:
REYMOND, JEAN-LOUIS,KILCHMANN, FALCO
申请号:
CA3048285
公开号:
CA3048285A1
申请日:
2017.01.06
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The invention relates to a compound (F) (1a) or (1b) wherein R1 is selected from -I, -Br, -CI, -F, C1C6-alkyl, -O(CH2)mCH3, -(CH2)mOCH3, C1C6-haloalkyl, a cycloalkyl, a heterocycle, a aryl or heteroaryl, wherein R2 is selected from H, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, -CH2-(C3-C6-cycloalkyl), or -(CH2)rOCH3, wherein R3 is -NH2, -NH-R4, -NHC(=0)-R4, -NHC(=O)NH-R4, -NHC(=S)-R4 or -NHC(=S)NH-R4, wherein R4 is selected from a cycloalkyl, a heterocycle, a aryl or a heteroaryl, or -L-R5, wherein L is selected from C1-C5-alkyl, a cycloalkyl, a heterocycle, a aryl, or a heteroaryl, and R5 is selected from -OH, -CH2OH, -NH2, -COOH, -CONH2, -CONH-R6 or carboxylic acid isosteres, wherein R6 is selected from C1-C4-alkyl, with n, m and r being 0, 1, 2, 3, 4 or 5 and their use.
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