CUSHING, TIMOTHY D.,DUQUETTE, JASON A.,HE, XIAO,LOHMAN, JULIA WINSLOW,SHIN, YOUNGSOOK
申请号：
PE0018292012
公开号：
PE03392013A1
申请日:
2011.04.01
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Relates to Heterocyclic compounds of formula (i), (ii) or (iii) where X1 is C (R10) or n, where H is R10, Halo, CN, among others x2 is C (R12) or n, where R12 is H or alkyl (c1-c4) X3 X4, X5 and x6 are each c or N and is N (R8), or s, where R8 is H or alkyl (C1 - C6) Z is o, s or nr11, Where R11 is H or alkyl (c1-c4) n is 0 to 3 r1 is a bicyclic Ring of 8 to 11 members.A Ring monociclico 3 to 7 members, alkyl (c1-c4), among others R2 is H, Nitro, among others Halo, Halo, R3 is H, alkyl (c1-c4), among others R4 is Halo, Nitro, CN, among others R5 is H, alkyl, Halo (C1 - C6), among others R6 h, Halo, Oh, among others R7 is H, haloalquilo (c1-c4), CN, between Others.Preferred compounds are: 1 - 2-cyclopropyl-1 - N - methyl - 2 - ((1S) - 1 - (9H purin - 6 - ilamino) ethyl) - 1H benzimidazole - 7 - carboxamide 2 - ((1R) - 1 - ((6 - amino - 5 - cyano - 4 - pirimidinil) amino) Ethyl) - 1 - (5 - fluoro - 3-pyridinyl) - n-methyl - - 7 - 1H benzimidazole carboxamide among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of phosphatidylinositol 3 - kinase (PI3K) being useful in the treatment of rheumatoid arthritis, Ankylosing Spondylitis, and psoriasisSE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I), (II) O (III) DONDE X1 ES C(R10) O N, EN DONDE R10 ES H, HALO, CN, ENTRE OTROS X2 ES C(R12) O N, EN DONDE R12 ES H O ALQUILO(C1-C4) X3, X4, X5 Y X6 SON CADA UNO C O N Y ES N(R8), O O S, EN DONDE R8 ES H O ALQUILO(C1-C6) Z ES O, S O NR11, EN DONDE R11 ES H O ALQUILO(C1-C4) n ES DE 0 A 3 R1 ES UN ANILLO BICICLICO DE 8 A 11 MIEMBROS, UN ANILLO MONOCICLICO DE 3 A 7 MIEMBROS, ALQUILO(C1-C4), ENTRE OTROS R2 ES H, HALO, NITRO, ENTRE OTROS R3 ES H, HALO, ALQUILO(C1-C4), ENTRE OTROS R4 ES HALO, NITRO, CN, ENTRE OTROS R5 ES H, HALO, ALQUILO(C1-C6), ENTRE OTROS R6 ES H, HALO, OH, ENTRE OTROS R7 ES H, HALOALQUILO(C1-C4), CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-CICLOPROPIL-N-METIL-2-((1S)-1-(9H-PURIN-6-ILAMINO)ETIL)-1H-BENZIMIDAZOL-7-CARBOXAMIDA
