Referring to a pirimidinona Derivative of formula (IID), where a is aryl heteroaryl C6 C20, 3 to 20 carbons with heteroatoms s, o or n, among others r1 is nrarb 2a is H, alkyl, Halo, Oh, CN, C1 - C6, among others R3 and R4 are H Halo, CN, NO2, c1-c6 alkyl, among others ra is heteroaryl 3 To 20 carbons with heteroatoms s, o or n, heterociclalquilo, heteroarilalquilo, RB is H, among othersC2 - C6 alkyl, alquinilo C2 - C6, among others. Preferred compounds are: 3 - methyl - 4 - phenyl - 7 - [1 - (9H purin - 6 - ilamino) ethyl] - 5 - [2 - [1,3] tiazolo ona] pyrimidine 5 -, 7 - {1 - [(2 - amino - 9h purin-6-yl) amino] ethyl] - 5 - [1,3] tiazolo [3.2] - pyrimidine - 5 - ona, 6 - (3-fluorophenyl) - 3 - methyl - 4 - [1 - (9H purin - 6 - ilamino) ethyl] - 5 - [1,3] tiazolo [3.2] - pyrimidine - 5 - ona, entr And others.It also relates to a Pharmaceutical composition. These compounds modulate the activity of the Kinases PI3K and are useful in the treatment of inflammatory disorders, cancer, immune, among othersREFERIDA A UN DERIVADO DE PIRIMIDINONA DE FORMULA (IId), DONDE A ES ARILO C6-C20, HETEROARILO DE 3 A 20 CARBONOS CON HETEROATOMOS S, O O N, ENTRE OTROS R1 ES NRARB R2a ES H, HALO, OH, CN, ALQUILO C1-C6, ENTRE OTROS R3 Y R4 SON H, HALO, CN, NO2, ALQUILO C1-C6, ENTRE OTROS RA ES HETEROARILO DE 3 A 20 CARBONOS CON HETEROATOMOS S, O O N, HETEROCICLALQUILO, HETEROARILALQUILO, ENTRE OTROS RB ES H, ALQUILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-METILO-6-FENILO-7-[1-(9H-PURIN-6-ILAMINO)ETILO]-5H-[1,3]TIAZOLO[3,2-a]PIRIMIDIN-5-ONA, 7-{1-[(2-AMINO-9H-PURIN-6-IL)AMINO]ETILO}-5H-[1,3]TIAZOLO[3,2-a]PIRIMIDIN-5-ONA, 6-(3-FLUOROFENIL)-3-METILO-7-[1-(9H-PURIN-6-ILAMINO)ETILO]-5H-[1,3]TIAZOLO[3,2-a]PIRIMIDIN-5-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS MODULAN LA ACTIVIDAD DE LAS QUINASAS PI3K Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS, INMUNOLOGICOS, CANCER, ENTRE OTRAS
