BAE, IN HWAN,SON, JUNG BEOM,HAN, SANG MI,KWAK, EUN JOO,KIM, HO SEOK,SONG, JI YOUNG,BYUN, EUN YOUNG,JUN, SEUNG AH,AHN, YOUNG GIL,SUH, KWEE HYUN
申请号：
PE0010482014
公开号：
PE14042014A1
申请日:
2012.12.27
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to compounds of thieno [3,2-d] pyrimidine of formula (i) where a is H, alkyl, cycloalkyl (C1 - C6) (C3 and C6), among others W is o, S, S (OR), among others X and y are each CH o n Z is H, alkyl (C1 - C3) or where nr3r4, R3 and R4 are each h, alkyl (C1 - C6), among others r1 is H, Hal Ogeno (C1 - C3), alkyl or alkoxy (C1 - C3) R2 is H, halogen, CF3 -, NO2 -,Among others M is 0 to 5 n is 0 to 2. Preferred compounds are: 4 - amino - N - (1 - (4-chlorophenyl) amino) - 6 - 5 - metilisoquinolin - il) thieno [3,2-d] pyrimidine 7 - carboxamide 4 - amino - N - (2 - methyl - 1 - ((3 - (trifluoromethyl) phenyl) isoquinolin amino) - 5 - IL) thieno [3,2-d] pyrimidine 7 - carboxamide among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of Protein Kinases to be useful in the treatment of gastric cancer, melanoma, psoriasisSE REFIERE A COMPUESTOS DERIVADOS DE TIENO[3,2-d]PIRIMIDINA DE FORMULA (I) DONDE A ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS W ES O, S, S(O), ENTRE OTROS X E Y SON CADA UNO CH O N Z ES H, ALQUILO(C1-C3) O NR3R4, DONDE R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS R1 ES H, HALOGENO, ALQUILO(C1-C3) O ALCOXI(C1-C3) R2 ES H, HALOGENO, -CF3, -NO2, ENTRE OTROS m ES DE 0 A 5 n ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: 4-AMINO-N-(1-((4-CLOROFENIL)AMINO)-6-METILISOQUINOLIN-5-IL)TIENO[3,2-d]PIRIMIDIN-7-CARBOXAMIDA 4-AMINO-N-(6-METIL-1-((3-(TRIFLUOROMETIL)FENIL)AMINO)ISOQUINOLIN-5-IL)TIENO[3,2-d]PIRIMIDIN-7-CARBOXAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASAS DE LAS PROTEINAS SIENDO UTILES EN EL TRATAMIENTO DEL CANCER GASTRICO, MELANOMA, PSORIASIS
