VISSER, Michael Scott,PAPILLON, Julien,LUZZIO, Michael Joseph
申请号：
PE2017000177
公开号：
PE20170241A1
申请日:
2015.08.05
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to two formula compounds, in which X is n or Cr； R2, R3 and R4 are independent h, halide, hydroxyl, etc.； R5 is h, CH3, ch2f, etc.； r5a and r5b are h, optional alternative C1-C3 tar or r5a and r5b are combined to form a methylene or ethylene Bridge Group； r5c and R5d are h, F, oh, Between other types of r5c and R5d, if a group of methylene and vinyl o-ch2-o is formed； R6, R7 and R8 are independent h, halogen, C1-C3, C1-C3 halides and other types, or R6 and R8 are a carbohydrate ring, etc., then the two will be related. 1. The preferred compound is 3-amino-n (3 - (4-aminopiperidin-1-il) pyridine-2-il) - 6 - (3 - (trifluoroid) pyridine-2-il) pyridine-2-carboxamida；3-amino-n - (3 - (4-aminopirin-1-il) piridin-2-il) - 6 - (3 - (trifluorometoxi) piridin-2-il) pirazina-2-carboxamida, etc. These compounds are inhibitors of proquinolase, which are used to treat autoimmune diseases and allergic reactions.Se refiere a compuestos de formula II, donde: X es N o CR； R2, R3 y R4 son independientemente H, halogeno, hidroxilo, entre otros； R5 es H, CH3, CH2F, entre otros； R5a y R5b son H, alquilo C1-C3 opcionalmente sustituido o R5a y R5b se unen entre si formando un grupo de puente metileno o etileno； R5c y R5d son H, F, OH, entre otros o R5c y R5d se unen entre si formando un grupo de metileno, etileno o -CH2-O； R6, R7 y R8 son independientemente H, halo, alquilo C1-C3, haloalquilo C1-C3, entre otros o R6 y R8 forman un anillo carbobiciclico, entre otros. Son compuestos preferidos: 3-amino-N(3-(4-aminopiperidin-1-il)piridin-2-il)-6-(3-(trifluorometil)piridin-2-il)pirazina-2-carboxamida； 3-amino-N-(3-(4-aminopiperidin-1-il)piridin-2-il)-6-(3-(trifluorometoxi)piridin-2-il)pirazina-2-carboxamida； entre otros. Dichos compuestos son inhibidores de la proteina C quinasa, siendo utiles en el tratamiento de enfermedades autoinmunes, reaccion alergica, entre otros
