Goehring, R. Richard,Matsumura, Akira,Shao, Bin,Taoda, Yoshiyuki,Tsuno, Naoki,Whitehead, John,Yao, Jiangchao,Fuchino, Kouki
申请号：
ES11188205
公开号：
ES2593706T3
申请日:
2008.08.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound according to Formula (II): ** Formula ** or a pharmaceutically acceptable derivative thereof wherein: Y1 is O； Q is selected from fused benzo or heteroaryl (5 or 6 members)； each R2 is independently selected from: (a) -halo, or -CN； or (b) -C1-C6 alkyl； a is an integer selected from 0, 1 or 2； the dashed line in the 6-membered nitrogen-containing ring that is fused to group Q indicates the presence or absence of a bond, and when that dashed line indicates the presence of a bond, then R3 and R4 are absent ； R3 is selected from: (a) -H； or (b) -C1-C4 alkyl which is unsubstituted or substituted with 1, 2 or 3 groups independently selected from -OH, -C1-C4 alkoxy, -N (R6) 2, -C ( >； = O) OR9, or -C (>； = O) N (R6) 2； or (c) -C3-C7 cycloalkyl which is unsubstituted or substituted with 1, 2 or 3 groups independently selected from -OH, -C1-C4 alkyl, -C1-C4 alkoxy, -N (R6) 2, -C (>； = O) OR9, or -C (>； = O) N (R6) 2； each R4 is independently selected from: (a) -H； or (b) -halo, -CN, or -NO2； or (c) -X, -C1-C6 alkyl-X, -heterocycle (5 or 6 members) -X, -heterocycle (5 or 6 members) -C1-C6 alkyl -X； or (d) -C (>； = Y) CN, -C (>； = Y) X, -C (>； = Y) T3, -C (>； = Y) YX, -C (>； = Y) YT3, - C (>； = Y) N (T1) (T2), -C (>； = Y) N (R9) CN, -C (>； = Y) N (R9) X, - C (>； = Y) N (R9 ) YH, -C (>； = Y) N (R9) YX, -C (>； = Y) N (R9) YCH2X, -C (>； = Y) N (R9) YCH2CH2X, or -C (>； = Y) N (R9) S (>； = O) 2T3； or (e) -N (R9) X, -N (R9) -CH2X, -N (R9) -CH2CH2X, -N (R9) CH2N (R9) C (>； = N (R12)) N (R12) 2 , -N (R9) - CH2CH2N (R9) C (>； = N (R12)) N (R12) 2, -N (T1) (T2), -N (T3) C (>； = Y) T3, -N (T3) C (>； = Y) YT3, -N (T3) C (>； = Y) N (T1) (T2), -N (T3) S (>； = O) 2T3, or -N (T3) S (>； = O) 2N (T1) (T2)； or (f) -CH2YH, -CH2CH2YH； or (g) -S (>； = O) T3, -S (>； = O) 2T3, -S (>； = O) N (T1) (T2), -S (>； = O) 2N (T1) (T2 ), -S (>； = O) X, or -S (>； = O) 2X； X is: (a) -H, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -C1-C6 al
