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Imidazopyridazines as inhibitors of PAR1, their obtaining and use as a medicine
专利权人:
SANOFI
发明人:
HEINELT, Uwe,WEHNER, Volkmar,HERRMANN, Matthias,SCHOENAFINGER, Karl,STEINHAGEN, Henning
申请号:
ES09707983
公开号:
ES2603302T3
申请日:
2009.01.23
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of the formula I ** Formula ** and / or all stereoisomeric or tautomeric forms of the compound of the formula I and / or mixtures of these forms in any proportion, and / or a salt of the compound of the formula I compatible from the physiological point of view, with Q1, Q2 and Q3 being the same or different, and representing, independently of each other, hydrogen atom or - (C1-C6) -alkyl, the hydrogen atoms in alkyl being able to be completely or partially substituted by fluorine, R1, R2 and R3 being the same or different, and independently representing each other, hydrogen atom, - (C1-C6) -alkyl, - (C3-C6) -cycloalkyl, -O- (C1-C8) -alkyl, -O- (C3-C6) -cycloalkyl, - (C0-C4) -alkylene-C (O) -N (R11) -R12, - (C0- C4) -alkylene-C (O) -O-R11, - (C0-C4) -alkylene-C (O) -R11, - (C0-C4) -alkylene-N (R11) -R12, - (C0-C4) -alkylene-N (R11) -C (O) - R12, halogen, OH, -CN, - (C1-C6) -alkylene-O- (C1-C6) -alkyl, -O- (C1-C6) -alkylene-O- (C1-C6) -alkyl -O- (C1-C4) - alkylene- (C3-C6) -cycloalkyl, no alkyl, alkylene and cycloalkyl being substituted respectively, or being substituted once, twice or three times, independently of each other, by - (C1-C4) -alkyl, OH or -O- (C1-C6) -alkyl, or the hydrogen atoms in alkyl, alkylene or cycloalkyl completely or partially substituted by fluorine, with the proviso that at least one R1, R2 or R3 is not hydrogen atom, representing R11 and R12, independently of each other, hydrogen atom, - ( C1-C6) -alkyl or - (C3-C6) -cycloalkyl, R4, R5, R6, R7 and R8 being the same or different and independently representing hydrogen atom, - (C1-C6) -alkyl, - (C3-C6) -cycloalkyl, OH, -CN, -O- (C1-C8) -alkyl, -O- (C3-C6) -cycloalkyl, - (C0-C4) -alkylene- (CO) - N ( R21) -R22, - (C0-C4) -alkylene-C (O) -O-R21, halogen, -SF5, - (C0-C4) -alkylene-C (O) -R21, - (C0-C4) -alkylene-N (R21) - R22, - (C0-C4) -alkylene-N (R21) -C (O) -R22, - (C1-C6) -alkylene-O- (C1-C6) -alkyl, - (C0-C6) -alkylene-O- (C1-C6) -alkylene-O- (C1-C6) -alq uyl, or - (C0-C6) -alkylen
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