A method for the treatment of a disease mediated by p38 other than cancer, which comprises administering a compound of formula I ** formula ** in which B is an aryl or heteroaryl moiety until substituted or unsubstituted tricyclic which may have up to 30 atoms of carbon having at least a 5 or 6 member aromatic structure containing 0-4 members of the group consisting of nitrogen, oxygen and sulfur, in which if B is a substituted group, it is substituted with one or more substituents independently selected from the group constituted by halogen, until perhalosubstitution, and Xn, in which n is 0-3 and each X is independently selected from the group consisting of -CN, -CO2R5, -C (O) NR5 R5 '', -C (O) R5, -NO2, -OR5, -SR5, -NR5 R5 '', -NR5 C- (O) -OR5 '', -NR5 C (O) R5 '', C1-C10 alkyl, C2-C10 alkenyl, C1- alkoxy C10, C3-C10 cycloalkyl, C6-C14 aryl, C7-C24 alkaryl, C3-C13 heteroaryl, C4-C23 alc-heteroaryl, substituted C1-C10 alkyl, substituted C2-C10 alkenyl ituido, substituted C1-C10 alkoxy, substituted C3-C10 cycloalkyl, substituted C4-C23 alc-heteroaryl and -Y-Ar； in which if X is a substituted group, it is substituted with one or more substituents independently selected from the group consisting of -CN, -CO2R5, -C (O) R5, -C (O) NR5 R5 '', -OR5, - SR5, -NR5 R5 '', - NO2, -NR5 C- (O) R5 '', - NR5 C- (O) OR5 '', and halogen until per-replacement； where R5 and R5 '' are independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C3-C10 cycloalkyl, C6-C14 aryl, C3-C13 heteroaryl, C7-C24 alkaryl, C4-C23 alkyl-heteroaryl, alkyl C1-C10 to per-halosubstituted, cycloalkyl C3-C10 to per-halosubstituted, alkenyl C2-C10 to per-halosubstituted, aryl C6-C14 to per-halosubstituted and heteroaryl C3-C13 to per-halosubstituted, where Y is -O- , -S-, -N (R5) -, - (CH2) -m, -C (O) -, -CH (OH) -, - (CH2) mO-, - (CH2) mS-, - (CH2 ) mN (R5) -, -O (CH2) m-, -CHX to -, -NR5 C (O) NR5 R5 '' -, -NR5 C (O) -, -C (O) NR5 -, -CX a2 -, -S- (CH2) m- and -N (R5) (CH2) m-, m = 1-3, and X a is halog
