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Diaminopyrimidines useful as inhibitors of human respiratory syncytial virus (RSV)
- 专利权人:
- AbbVie Inc.
- 发明人:
- DEKHTYAR, Tatyana,GOMTSYAN, Arthur,MOLLA, M-Akhteruzzaman,VASUDEVAN, Anil,NG, Teresa (Iok Chan),CHAFEEV, Mikhail
- 申请号：
- ES13706396
- 公开号：
- ES2655177T3
- 申请日:
- 2013.02.15
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- A compound having formula (1), or a pharmaceutically acceptable salt thereof, ** (See formula) ** where: R 1 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 8 cycloalkyl, C 3 cycloalkyl -C8-C1-C9 alkyl, phenyl, bicyclic aryl, phenyl-C1-C6 alkyl, heterocyclyl, heterocyclyl-C1-C6 alkyl, monocyclic heteroaryl or monocyclic-C1-C6 alkyl； wherein the C3-C8 cycloalkyl, the C3-C8 cycloalkyl of C3-C8-alkyl-C1-C6 alkyl, heterocyclyl and heterocyclyl heterocyclyl-C1-C6 alkyl are optionally substituted with 1, 2, 3 or 4 substituents selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C2-C10 haloalkenyl, C2-C10 haloalkynyl, halogen, oxo, cyano, hydroxy, -O-C1-C6 alkyl, -O-haloalkyl-C1-C6, - alkylene-C1-C3-OH, -alkylene-C1-C3-O-alkyl-C1-C6, -alkylene-C1-C3-O -haloalkyl-C1-C6, -alkylene-C1-C3-NH2, - NH2, -C (O) O-C1-C6-alkyl, -N (Rb1) C (O) Rb1, -CON (Ra1) (Rb1 ), -C (O) Rb1, -OC (O) Rb1, -OS (O) 2N (Ra1) (Rb1), -CO2H, - CO2Rb1, -N (Rb1) C (O) N (Rb1) 2, -S-Rb1, -S (O) 2Rb1, -S (O) Rb1, -SO2N (Ra1) (Rb1), -N (Ra1) (Rb1), -N (Rb1) S (O) 2Rb1, - N (Rb1) C (O) O (Rb1), -N (Rb1) S (O) 2O (Rb1), -L1a-O-Rb1, -L1a-CN, -L1a-N (Rb1) C (O) Rb1 , -L1a-CON (Ra1) (Rb1), -L1a- C (O) Rb1, -L1a-OC (O) Rb1, -L1a-CO2H, -L1a-CO2Rb1, -L1a-N (Rb1) C (O ) N (Rb1) 2, -L1a-S-Rb1, -L1a-S (O) 2Rb1, -L1a-S (O) Rb1, -L1a-SO2N (Ra1 ) (Rb1), -L1a-N (Ra1) (Rb1), -L1a-N (Rb1) S (O) 2Rb1 and -L1a-N (Rb1) C (O) O (Rb1)； wherein the phenyl, bicyclic aryl, phenyl-C1-C6-alkyl phenyl, monocyclic heteroaryl and monocyclic heteroaryl-C1-C6-alkyl heteroaryl are optionally substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of halogen, C1-C6 alkyl, halo-C1-C6 alkyl, -OCH2O-, -O-Rb, -CN, -N (Rb) C (O) Rb, - CON (Ra) (Rb), -C (O) Rb, -OC (O) Rb, -OS (O) 2N (Ra) (Rb), -CO2H, -CO2Rb, -N (Rb) C (O) N (Rb) 2, -S -Rb, -S (O) 2Rb, - S (O) Rb, -SO2N (Ra) (Rb), -N (Ra) (Rb), -N (Rb) S (O) 2Rb, -N (Rb ) C (O) O (Rb), -N (Rb) S (O) 2O (Rb), -L1-O-Rb, -L1-CN,
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
